Clinical and Social Pharmacy

Ph.D. studium

  1. General Information
  2. Entrance Examination
  3. Framework Study Plan
  4. Human Resources
  5. Research Groups

1. General Information

  • Form of study:

full-time / combined

  • Language of study:

Czech / English

  • Standard length of study:

4 years

  • Form of entrance examination:


  • Validity of accreditation:

until 28th November 2028

  • Education field:

Pharmacy (100 %)

Study Program Characteristics

Clinical pharmacy and social pharmacy are applied fields of pharmacy that complement each other. Clinical pharmacy follows an individual approach to the rational use of drugs and as an important knowledge and skill base for pharmaceutical care. Social pharmacy looks at pharmaceutical services from the perspective of society and analyzes the usefulness of pharmaceutical services to society at present and from historical experience. Both views of pharmacy complement each other and give a unique comprehensive view of pharmacotherapy and the role of drugs from the perspective of the individual and society.

Information on Graduate Employment

The graduate of Clinical Pharmacy

  • has knowledge and skills how to reach rational choice and use of medicines;
  • is able to manage methodology of Pharmacoepidemiology, Pharmacoeconomics; Health Technology Assessment and Pharmacovigilance in evaluation of the therapeutic value of drugs;
  • is able to monitor behavior of health care workers and patients during pharmacotherapy (drug compliance, adherence, drug related problems) and is able to find tools for minimization of risks of pharmacotherapy.

The graduate of Social Pharmacy

  • knows the principles of medicine policy and is able effectively use its tools;
  • is able to critically assess literature information regarding pharmacotherapy;
  • is able to analyze needs and marketing services of contemporary Pharmacy from the historical point of view. 

2. Entrance Examination

Framework Content of the Entrance Examination

Oral exam from the knowledge of pharmakoepidemiology, knowledge of social pharmacy and risk management in pharmacotherapy for clinical pharmacy.

English language exam for English language knowledge assessment (C1 at least).

Conditions of Admission

  1. Admission to Doctoral studies is conditioned by successful completion of a Master's study programme.
  2. Successful passed the entrance exam.

Additional Conditions for Bonus Points (e.g. Practice)

  • Graduation of university master study in pharmacy or medicine (rated 2 points for brunch of clinical pharmacy).
  • Graduation of any university master study related to pharmacy, medicine, economy, psychology, sociology, informatics (rated 2 points  for brunch of social pharmacy).
  • Diploma thesis of applicant links with respect to the Ph.D. study subprogram of particular candidate related to medication policy, sociology, psychology, economy, pharmacoeconomy, pharmaceutical and health care low, risk of pharmacotherapy, medication errors, pharmacoepidemiology, clinical pharmacy, pharmaceutical care or clinical physiology of nutrition (rated with 3 points).
  • Indication of the supposed training center and the approval of a specific supervisor with the management of the planned doctoral project (rated max. 5 points).

Criteria for the Evaluation Exams

  1. Professional knowledge level – reviewed on answers to questions stated in General content of entrance exam (max. up to 10 points)
  2. Submitted doctoral project – evaluation of project complexity, modern methodological approaches to solution, and the continuity of the project on topics already discussed by the Subject Area Board (max. up to 10 points)

The minimum admission limit is 20 points.

The Dean decides to accept the applicant(s) who have fulfilled the conditions of the admission procedure and, according to the number of points achieved, ranked in the order corresponding to the predetermined number of accepted applicants for the particular program.


3. Framework Study Plan

Study obligations

PhD program is individualized for each student. It is necessary to pass at least two exams + exam from English language. Topic of exam:
1.    Community health care
2.    Methodology pf scientific work
3.    Social medicine
4.    Social pharmacy
5.    Economy and management in health care
6.    Health and medicine policy
7.    Pharmacoepidemiology
8.    Quality of health care and its measurement
9.    Quality of life an indicator of therapy outcome and its measurement
10.  History and trends pharmaceutical care
11.  Pharmacoinformatic and management of drug information centre
12.  Pharmacoeconomic and health technology assessment
13.  Basic pf pharmacology
14.  Selected topic from pathophysiology
15.  Geriatric pharmacotherapy - polypharmacy, specific in selection on pharmacotherapy by elderly
16.  Clinical pharmacokinetic
17.  Basic of physiology
18.  Selected chapters from internal medicine, neurology and psychiatry
19.  Pharmaceutical care
20.  Clinical pharmaceutical care
21.  History of pharmacy and propaedeutic of pharmaceutical research

Publication activity requirements

Necessary for successful defences of dissertation work is continual publication activity – at least two papers in journal with IF. By one of them it is necessary to be 1st author. Second option is to publish as a 1st author in Journal with IF > 5 or in 1st Q.

A particular exception has students in specialization of social pharmacy and pharmacy practice which will be decide by chair of professional board of clinical and social pharmacy   

Requirements for completing internships

Abroad internship in duration of 3 months is integral part of study program.

Other study obligations

It is necessary to present result of research on different scientific events and for students of present study to participate in teaching program if they past state exam (max. 20 hours per term in subjects: Social pharmacy, Pharmaceutical care Clinical pharmaceutical care; they should to analyse cases from Drug information centre).

Generally: to pass state exam from clinical & social pharmacy, defences of dissertations work and prepare 20 cases of patients with polypharmacotherapy and with algorithm SAFE (for specialization in clinical pharmacy).

Another duties are specified in individual study plan.

Dissertation themes

  • Examples of successfully defended dissertations
    • The aspects influencing the therapeutic value of anticoagulants in the Czech Republic
    • Changes in nutrition, resting energy expenditure, and body composition of Czech women during pregnancy and lactation in relation to birth parameters and milk production.
    • Contextual analysis of medication adherence in patients after kidney transplantation
    • Risks Associated with the Dietary Supplements Use.
    • Selected aspects of methotrexate treatment in patients with rheumatoid arthritis
  • Themes of defended dissertations - Thesis repository
  • List of current doctoral dissertation themes

State Doctoral Examination

State exam – specialization for clinical pharmacy is divided to 3 section A – B – C

Section A:

By nosologically units has student to show skills and knowledge to define goals of treatment, basic possibilities of diagnosis necessary for rational choice of drugs and strategy of acute and chronic phase of disease and to list possible errors  by receiving goals  (how to use medicine, medicine non-adherence; life style , comedication incl. Self-medication and monitoring).

Strategy related with pharmacotherapy to define basic dosage scheme and basic risk- ADR, Drug interaction, contraindication and usually medication errors and to look for  way how to minimize this risk.

  • Arterial hypertension;
  • Congestive heart failure;
  • Dysrhythmia;
  • Painful form of ischemic heat disease;
  • Peripheral artery disease;
  • Deep venous thrombosis;
  • Stroke;
  • Chronic pain;
  • Acute pain;
  • Primary and secondary prevention of atherosclerosis;
  • Gastroesophageal reflux disease;
  • Diarrhoea;
  • Constipation;
  • Inflammatory bowl disease;
  • Pancreatitis;
  • Renal failure;
  • Asthma bronchial;
  • Chronic obstructive pulmonary disease;
  • Depression;
  • Dementia;
  • Schizophrenia;
  • Bipolar disorder;
  • Epilepsy;
  • Parkins disease;
  • Headache;
  • Benign prostatic hyperplasia and urinary incontinence;
  • Basic principle of rational use of infection disease;
  • Infection disease of respiratory ways;
  • Infection disease of urinary ways;
  • System viral disease;
  • Anaemia;
  • Thyreopathy;
  • Goat; Rheumatic arthritis;
  • Sleep disorder;
  • Diabetes mellitus;
  • Osteoporosis;
  • Leukaemia.

Section B:​

Analysis of ADR ev. signals of ADR and theory of three pillars: 1/ risk factors; 2/way of monitoring and when and 3/ ways of risk minimization on the level how to use medicine; medication adherence, monitoring medication review, life style and supporting treatment by OTC and good supplements.

  • Changes of kalaemia, calcemia a magnesemia, glycaemia, blood pH, creatinemia, uric acid;
  • Bradycardia, tachycardia;
  • Visual toxicity;
  • Constipation;
  • Diarrhoea;
  • Cough;
  • Creatine kinase;
  • Increasing ALT, AST, lactate;
  • Prolongation QT interval;
  • Pharmacotherapy of elderly;
  • Pharmacotherapy of pregnant and nursing women;
  • Pharmacotherapy of kids;
  • Pharmacotherapy by renal failure;
  • Pharmacotherapy of liver disease;
  • Genomic signals of risk of pharmacotherapy;
  • Signals of non appropriate use of antibiotics;
  • Pharmacokinetic signals of risk of pharmacotherapy and use TDM in individualization of pharmacotherapy.
  • Pharmacoepidemiologic signals of risk of pharmacotherapy and their use to signal building and founding of benefit/risk ratio in algorithm of SAFE.

Section C:

Student will collect 20 cases and will analyse them – if the goal were reached (incl. theoretically) and manages risk minimization of risks in particular case with algorithm SAFE. One of this cases will be selected by lot and student will present it.

The State Doctoral Exam for Social Pharmacy will be conducted from three areas.

The exam topics will be discussed from the perspective of general principles of management, regulation and use of tools to achieve the objectives of various policies (health, drug, antibiotic, social), regulatory tools to ensure availability, quality, efficacy and safety of drugs and analysis of regulatory effectiveness from an international perspective, critical analysis of experience in the Czech Republic and inclusion in the international and historical context.

  1. Characteristics of developmental stages of pharmacy and their reflection in the Czech national past, place and role of pharmacy in health care development
  2. Pharmaceutical historiography and museology - characteristics, function, importance, museums
  3. Social pharmacy - characteristics, scope, position in the system of pharmaceutical sciences, relation to social medicine
  4. Theory of health and illness - definition of health and illness, stages of illness, causes of illness, importance
  5. Health state of population - indicators, determination, problems
  6. Overview of health systems - characteristics, their advantages and disadvantages
  7. Social policy and social care in the Czech Republic - characteristics, systems, position, principles, problems
  8. Health policy in the Czech Republic - characteristics, individual influential subjects, concepts, problems
  9. Drug policy in the Czech Republic - characteristics, goals, individual influential subjects, aspects, tools and their regulatory possibilities, comparison with foreign
  10. Health care management in the Czech Republic - organizational structure, position of the Ministry of Health, regions and municipalities, problems
  11. Medical preventive care - characteristics, classification, outpatient and inpatient health care facilities, quality of care - accreditation of health care facilities
  12. Public health protection - hygiene service, preventive medicine - classification, legal regulations, organization, principles of work
  13. Health promotion - status, importance, themes, methodology, health education
  14. Health insurance - principles, status, models of health insurance and their advantages and disadvantages, institutions, availability of health care
  15. Health care financing - overview, individual payers (patient, health insurance, other payers), capitation, fee for service
  16. Reimbursement of medicinal products - general principles, their practical application, differentiation of reimbursement of medicines to pharmacies or other medical facilities
  17. Ethics in health care - ethical aspects of health care, rights and obligations of health care workers and patients, professional regulations of the Czech Medical Chamber, ethical codes in health care and industry, ethics in drug testing - ethics committees, ethical problems
  18. Health care workers - categories, legislation, education and further education,legal responsibility, problems
  19. Pharmacists - legislation, scope of activities, division of labor, education, legal responsibility, ethics of the profession
  20. International cooperation in healthcare and pharmacy - importance, organization, status, tasks (WHO, Red Cross, FIP, PGEU, ESCP, EAHP, etc.)
  21. Professional organizations of pharmacists and other health workers - importance, status, legal regulations
  22. Pharmaceutical research - characteristics, tasks, methods, institutions, future
  23. Pharmaceutical industry - characteristics, specifics of pharmaceutical production, good manufacturing practice, marketing, future trend
  24. Pharmaceutical wholesalers - characteristics, good distribution practice, problems, future trends
  25. Pharmaceutical control - characteristics, status, tasks, institutions, future trends
  26. Drug control - classification, individual stages, drug safety, pharmacovigilance
  27. Pharmaceutical education - classification, scope, tasks, current situation, future
  28. Good practices in pharmacy - general principles, characteristics of different types, importance
  29. Pharmacoepidemiology - characteristics, subject of interest, methods, basic types of studies, importance
  30. Pharmacoeconomics - characteristics, methods, importance, drug consumption
  31. Pharmaco-informatic - characteristics, roles, drug related information sources, evidence-based medicine (EBM)
  32. Pharmacopoeia and similar literature - characteristics, importance, development, current state, problems
  33. Basic legislation in health care in the Czech Republic
  34. Basic legislation in pharmacy in the Czech Republic
  35. Pharmaceuticals (medicines, drugs) - legislation, nomenclature, ethical and generic drugs, orphan drugs, OTC drugs, licensing, registration, drug relationship and Para pharmaceuticals
  36. Issues of addictive substances and precursors - legislation, classification, treatment, drug addiction, abuse
  37. Counterfeit Medicines (falsification of drugs) - characteristics, importance, possibilities of risk reduction
  38. Advertising of pharmaceuticals - importance, legislation, regulation; pharmacy advertising - overall
  39. Pharmaceutical care - definition, characteristics of individual elements, current state, future trends, drug records of the patient
  40. Pharmacy care - good pharmacy practice, legislation, individual activities, inspections, economics, objective monitoring of activity and quality of provided services
  41. Psychology and sociology in pharmacist´s work - communication with patients, cooperation with other health care workers, managerial activity, public activity of pharmacist in society
  42. Medication errors - reasons, risks, possibilities of solution
  43. Patient and drugs - problems, compliance, adherence and concordance, addiction, drug abuse
  44. Self-medication - definition, general algorithm of choice of appropriate therapy, alternative pharmacy and medicine
  45. Dispensing activity in pharmacy - characteristics, extent, dispensation of medicinal products, influencing patient compliance, modern methods of cooperation pharmacist - patient - doctor
  46. Preparation of medicinal products in pharmacies - characteristics, importance, scope, legislation, good pharmacy practice in the field of preparation, specifics of preparation in public and hospital pharmacies
  47. Economics of pharmacy care - pricing in pharmacy, income and costs of pharmacy, cooperation with health insurance companies, economic administration, marketing
  48. Hospital pharmacy - importance, tasks, specifics, problems
  49. Clinical pharmacy - characteristics, importance, practical application, problems, future trends
  50. Other professional activities and specialized services in pharmacy - control, supply, information and consultancy, educational activities; specialized servicesn for patients and healthcare facilities; unused medicines - legislation, definitions, reasons, risks, possibilities of solution

4. Human Resources

Subject Area Board

Subject Area Board Chair and study program guarantor

  • prof. PharmDr. Přemysl Mladěnka, Ph.D.

Members of Subject Area Board

  • doc. MUDr. Svatopluk Býma, CSc.
  • doc. Dipl.-Math. Erik Jurjen Duintjer Tebbens, Ph.D.
  • doc. PharmDr. Daniela Fialová, Ph.D.
  • doc. PharmDr. Miloslav Hronek, Ph.D.
  • doc. RNDr. Jozef Kolář, CSc.
  • doc. PharmDr. Hana Kubová, DrSc.
  • doc. PharmDr. Josef Malý, Ph.D.
  • prof. PharmDr. Petr Nachtigal, Ph.D.
  • prof. MUDr. Vladimír Palička, CSc., dr. h. c.
  • prof. PharmDr. Petr Pávek, Ph.D.
  • prof. MUDr. Roman Prymula, CSc., Ph.D.
  • doc. MUDr. Tomáš Soukup, Ph.D.
  • doc. MUDr. Alena Šmahelová, Ph.D.
  • prof. PharmDr. František Štaud, Ph.D.
  • prof. PharmDr. František Trejtnar, CSc.
  • prof. RNDr. Jiří Vlček, CSc.

Other members of the State Doctoral Examination and Dissertation Defense Committees other than the members of the Subject Are Board

  • doc. PhDr. František Dohnal, CSc.
  • doc. MUDr. Lenka Hodačová, Ph.D.
  • prof. MUDr. Roman Chlíbek, Ph.D.
  • prof. MUDr. Ladislav Jebavý, CSc.
  • prof. PhDr. Jiří Mareš, CSc.

5. Research Groups

Research groups lead by supervisors of doctoral study program Clinical and Social Pharmacy

Analysis of the therapeutic value, need and consumption of drugs and the development of pharmacy

Clinical & Social Pharmacy and History of Pharmacy
Group leader: doc. PharmDr. Josef Malý, Ph.D.
Pharmacoepidemiology and Clinical Pharmacy | History of Health Care and Pharmacy

Ageing, Polypharmacy and Changes in the Therapeutic Value of Drugs in the Aged Unit
Group leader: doc. PharmDr. Daniela Fialová, PhD.

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