Research Areas

Cooperatio Program “Pharmaceutical Sciences”

The Charles University Cooperatio Program “Pharmaceutical Sciences” (PharmSci) aims to coordinate research activities at 6 faculties of the Charles University: the Faculty of Pharmacy in Hradec Králové and all five Faculties of Medicine.

The most important priority in the PharmSci research area is to increase in its overall quality, outcomes and implementation of the research results in practice. We aim to further strengthen our infrastructure and capacities for the development of excellence in research and innovation, to substantially extend the long-term cooperation with the application sector, to foster international collaboration in the research, and to make use of the infrastructure both for research and education.

Our key priority is to stimulate and motivate academic and research staff to focus on the outreach of their research. We emphasize quality over quantity of publications.

Another priority is establishing larger multidisciplinary teams that can produce competitive, conclusive, and high-quality research results.

Board of the Program:

• Coordinator: prof. PharmDr. Tomáš Šimůnek, Ph.D.
• Deputy Coordinator: prof. MUDr. Ondřej Slanař, Ph.D.
• Members: Research Area Board Pharmaceutical Sciences

Faculty of Pharmacy in Hradec Králové

The research activities at the Charles University Faculty of Pharmacy involve all aspects of contemporary pharmaceutical sciences. A wide range of theoretical and experimental approaches are applied to study both new and established pharmaceuticals, predominantly small molecules of organic origin, with the capacity of ameliorating pathological processes in the human body.

For the PharmSci program, the research is organized by following Science Topics and Workgroups. Some of them have been newly established or reorganized in the transition between the PROGRESS and COOPERATIO programs.

• Syntheses of potential drugs and studies of structure-activity relationships

• Pharmaceutical analysis of drugs and other biologically active substances including the development and validation of new methods, especially using modern methods of sample preparation

• Studies of effects of drugs in various experimental pathological states

• Analyses of therapeutical value, consumption and need of drugs, and history of pharmacy

• Studies of the pharmacokinetic profiles of drugs with focus on interactions with transport and biotransformation proteins

• Research and development of dosage forms

• Study of secondary metabolites of pharmaceutically important plants, their biological activity and toxicity

• In silico models, statistics and other mathematical approaches used in pharmaceutical and biomedical sciences

Medical faculties

Charles University has five faculties of medicine, and the research at the field of Pharmaceutical Sciences involves a broad spectrum of activities within the areas of experimental and clinical pharmacology and toxicology.

The research has been organized by the following Science Topics and Workgroups:

First Faculty of Medicine

• Institute of Pharmacology, First Faculty of Medicine and General University Hospital in Prague
  • Clinical pharmacology
    Leader: prof. MUDr. Ondřej Slanař, Ph.D.
  • Experimental and molecular pharmacology
    Leader: MUDr. Nikolina Kutinová Canová, Ph.D.
  • Pre-clinical and clinical pharmacokinetics
    Leader: doc. PharmDr. Martin Šíma, Ph.D.
  • Population pharmacokinetics and pharmacometrics
    Leader: Mgr. Danica Michaličková Ph.D.
  • Clinical pharmacy
    Leader: PharmDr. Jan Hartinger, Ph.D.
• Department of Physiology
  • Leader: prof. MUDr. Jaromír Mysliveček, Ph.D.
    Neuropharmacology of G protein-coupled receptors
• Department of Occupational Medicine, 1st Faculty of Medicine, Charles University in Prague
  Leader: prof. MUDr. Sergej Zacharov, Ph.D.
   
• Institute of Forensic Medicine and Toxicology
  Leader: doc. Radomír Čabala, PhD

Second Faculty of Medicine

• Department of Pharmacology
  Leader: doc. RNDr. Eva Kmoníčková, CSc.

Third Faculty of Medicine

• Department of Pharmacology
  Leader: prof. MUDr. Jan Bultas, CSc.
  Leader: doc. MUDr. Martin Votava, Ph.D.
  Leader: doc. PharmDr. Magdaléna Šustková, CSc.
  Leader: doc. MUDr. Jiří Slíva, Ph.D.

Faculty of Medicine in Plzeň

• Department of Pharmacology and Toxicology
  Leader: prof. PharmDr. Radek Kučera, Ph.D. 

Faculty of Medicine in Hradec Králové

• Department of Pharmacology
  • Liver pharmacology
    Leader: prof. MUDr. Stanislav Mičuda, Ph.D.
  • Cardiotoxicity
    Leader:  doc. PharmDr. Martin Štěrba, Ph.D.
  • Clinical pharmacology
    Leader: doc. Ing. Jaroslav Chládek, CSc.