Doctoral Dissertation Themes

List of doctoral dissertation themes for the academic year 2022/2023

Bioanalytical Methods

• Chromatographic methods coupled to mass spectrometry for bioanalytical purposes
  Supervisor: prof. PharmDr. Lucie Nováková, Ph.D.
• New HPLC and UHPLC methods for clinical research and routine practice
  Supervisor: doc. RNDr. Lenka Kujovská Krčmová, Ph.D.

Bioorganic Chemistry

• Novel stereoselective rearrangements mediated by small molecules
  Supervisor: Dr. rer. nat. Mgr. Ing. Tomáš Hodík
• Synthesis and study of labeled ultra-long ceramides
  Supervisor: prof. PharmDr. Kateřina Vávrová, Ph.D.
  Consultant: PharmDr. Lukáš Opálka, Ph.D.

Pharmaceutical Chemistry

• Study of derivatives based on nitrogen heterocycles as potential antimicrobial agents
  Supervisor: prof. PharmDr. Martin Doležal, Ph.D.
  Consultant: PharmDr. Marta Kučerová, Ph.D.

Pharmaceutical Analysis

• Automation of analytical assays based on luminiscence detection for analytes of biological and pharmaceutical interest
  Supervisor: doc. PharmDr. Hana Sklenářová, Ph.D.
  Consultant: Dr. Burkhard Horstkotte
• Automation of methodologies based on luminiscence detection for analytes of biological and pharmaceutical interest
  Supervisor: doc. PharmDr. Hana Sklenářová, Ph.D.
  Consultant: Dr. Burkhard Horstkotte
• Automation of sample pre-treatment based on extraction procedures using sequential injection analysis III
  Supervisor: doc. PharmDr. Petr Chocholouš, Ph.D.
• Automation of solid phase extraction for modern separation methods
  Supervisor: doc. PharmDr. Hana Sklenářová, Ph.D.
  Consultant: Dr. Burkhard Horstkotte
• Host proteins detection in antobody biotherapeutics
  Supervisor: doc. PharmDr. Hana Sklenářová, Ph.D.
  Consultant: PharmDr. Juraj Lenčo, Ph.D.
• Chiral separations of borane clusters
  Supervisor: doc. PharmDr. Radim Kučera, Ph.D.
• Real time monitoring of content of biologically active substances using flow methods
  Supervisor: doc. PharmDr. Hana Sklenářová, Ph.D.
• Stability studies of selected active substances using modern analytical techniques
  Supervisor: doc. PharmDr. Hana Sklenářová, Ph.D.
  Consultant: doc. PharmDr. Ludmila Matysová, Ph.D.

Pharmaceutical Chemistry

• Synthesis and development of new antimicrobial compounds using Computer Aided Drug Design
  Supervisor: doc. PharmDr. Jan Zitko, Ph.D.

Pharmaceutical Technology

• Biopharmaceutical testing of mesoporous silica based systems
  Supervisor: doc. PharmDr. Barbora Vraníková, Ph.D.
  Consultant: prof. Dr. Martin Kuentz

Pharmacognosy and Nutraceuticals

• Arundo donax L. alkaloids and their biological activities related to Alzheimer's disease and cytotoxicity
  Supervisor: doc. PharmDr. Jakub Chlebek, Ph.D.
• Alkaloids of genus Narcissus (Amaryllidaceae): isolation, structural identification, biological activity II
  Supervisor: prof. Ing. Lucie Cahlíková, Ph.D.
• Isolation and biological activity of selected indole alkaloids
  Supervisor: PharmDr. Marcela Šafratová, Ph.D.
  Consultant: doc. PharmDr. Jakub Chlebek, Ph.D.
• Substances of natural origin useful in the prevention of cardiovascular diseases
  Supervisor: doc. Ing. Kateřina Macáková, Ph.D.

Pharmacology and Toxicology

• Differences in hemocoagulation in patients with metabolic disorders II
  Supervisor: prof. PharmDr. Přemysl Mladěnka, Ph.D.
  Consultant: PharmDr. Alejandro Carazo Fernández, Ph.D.
• Effect of nucleoside-derived antivirals on nucleoside homeostasis and modulation of inflammatory processes in the placenta
  Supervisor: doc. PharmDr. Lukáš Červený, Ph.D.
• Perspectives in nuclear receptors modulation with novel compounds
  Supervisor: prof. PharmDr. Petr Pávek, Ph.D.
• Pharmacological and toxicological effects of pollutants on the cardiovascular system
  Supervisor: prof. PharmDr. Přemysl Mladěnka, Ph.D.
  Consultant: PharmDr. Alejandro Carazo Fernández, Ph.D.
• Pharmacological intervention of endoglin expression and its signalling in selected pathological conditions
  Supervisor: prof. PharmDr. Petr Nachtigal, Ph.D.
• Study of stress-induced senescence in cardiac cells
  Supervisor: prof. PharmDr. Přemysl Mladěnka, Ph.D.
  Consultant: PharmDr. Eduard Jirkovský, Ph.D.
• The role of pharmacokinetic mechanisms in the anticancer drug resistance and their modulation
  Supervisor: doc. RNDr. Jakub Hofman, Ph.D.
• Use of cannabis in pregnancy; effect on placental functions
  Supervisor: prof. PharmDr. František Štaud, Ph.D.

Xenobiochemistry and Pathobiochemistry

• Anthracycline resistance in tumor cell lines induced by reductases from the Aldo-ketoreductase superfamily.
  Supervisor: prof. Ing. Vladimír Wsól, Ph.D.
• Epigenetic regulation of carbonyl-reducing enzymes in parasitic nematodes
  Supervisor: doc. Ing. Petra Matoušková, Ph.D.
• New inhibitors to overcome anthracycline resistance in cancer.
  Supervisor: prof. Ing. Vladimír Wsól, Ph.D.