Doctoral Dissertation Themes

List of doctoral dissertation themes for the academic year 2025/2026

Applied physics and mathematics in medicine and pharmacy

• Data-driven mathematical models of nuclear receptor-regulated gene expression dynamics
  Supervisor: Mgr. Veronika Bernhauerová, Ph.D.
  Consultant: doc. Dipl.-Math. Erik Jurjen Duintjer Tebbens, Ph.D.
• High-throughput reliable prediction of drug metabolism mechanism
  Supervisor: Eugen Hruška, Ph.D.
• Mathematical modeling for nuclear receptor-regulated gene expression dynamics
  Supervisor: doc. Dipl.-Math. Erik Jurjen Duintjer Tebbens, Ph.D.
  Consultant: Mgr. Veronika Bernhauerová, Ph.D.
• Quantitative prediction of drug metabolism
  Supervisor: Eugen Hruška, Ph.D.

Bioanalytical Methods

• Automation of QuEChERS-like sample preparation for modern separation techniques
  Supervisor: doc. Burkhard Horstkotte, M.Sc., Dr.
  Consultant: doc. PharmDr. Hana Sklenářová, Ph.D.
• Chromatographic methods coupled to mass spectrometry for bioanalytical purposes
  Supervisor: prof. PharmDr. Lucie Nováková, Ph.D.
• The use of advanced analytical techniques for detection and determination of contaminants in food and environmental samples
  Supervisor: prof. RNDr. Dalibor Šatínský, Ph.D.

Pharmaceutical Analysis

• Automated methodologies for analytes of biological and pharmaceutical interest based on luminiscence detection
  Supervisor: doc. PharmDr. Hana Sklenářová, Ph.D.
  Consultant: doc. Burkhard Horstkotte, M.Sc., Dr.
• Generic single and multidimensional HPLC middle-up analyses of antibody biopharmaceuticals
  Supervisor: doc. PharmDr. Juraj Lenčo, Ph.D.
• Multidimensional methods for analysis of pharmaceutical and bioanalytical samples based on automated extraction procedures and high-performance liquid chromatography
  Supervisor: doc. PharmDr. Petr Chocholouš, Ph.D.

Pharmaceutical Chemistry

• Design, synthesis, and evaluation of new antimicrobial compounds using computational modelling
  Supervisor: doc. PharmDr. Jan Zitko, Ph.D.
• Synthesis and study photosensitizers for photodynamic therapy
  Supervisor: doc. PharmDr. Veronika Nováková, Ph.D.

Pharmaceutical Technology

• Investigation of Topically Applied Organic UV Filters and Their Effects on the Microstructure and Function of the Skin Lipid Barrier
  Supervisor: doc. PharmDr. Andrej Kováčik, Ph.D.

Pharmacognosy and Nutraceuticals

• Arundo donax L. alkaloids and their biological activity.
  Supervisor: doc. PharmDr. Jakub Chlebek, Ph.D.
• Biological activity of Amaryllidaceae alkaloids and their semisynthetic derivatives in connection with Alzheimer´s disease
  Supervisor: prof. Ing. Lucie Cahlíková, Ph.D.
• Indole alkaloids and their neuroprotective activity
  Supervisor: doc. PharmDr. Jakub Chlebek, Ph.D.

Pharmacology and Toxicology

• Perspectives in nuclear receptors modulation with novel approaches (small molecules, allosteric modulators or degraders)
  Supervisor: prof. PharmDr. Petr Pávek, Ph.D.
• Perspectives in nuclear receptors modulation with novel approaches (small molecules, allosteric modulators or degraders)
  Supervisor: prof. PharmDr. Petr Pávek, Ph.D.
• Study of the role of pharmacokinetic mechanisms in the anticancer drug resistance and possibility of their pharmacological modulation
  Supervisor: doc. RNDr. Jakub Hofman, Ph.D.
• The impact of pharmacological and genetic modulation of endoglin expression and signaling cascades in cardiometabolic disorders in vivo.
  Supervisor: prof. PharmDr. Petr Nachtigal, Ph.D.

Xenobiochemistry and Pathobiochemistry

• Epigenetic regulation of carbonyl-reducing enzymes in parasitic nematodes
  Supervisor: doc. Ing. Petra Matoušková, Ph.D.
• Human Aldo-Keto Reductases in Breast Tumors and Their Contribution to Drug Resistance.
  Supervisor: prof. Ing. Vladimír Wsól, Ph.D.