Doctoral Dissertation Themes

List of doctoral dissertation themes for the academic year 2023/2024

Bioanalytical Methods

• Development of electrophoretic methods for analysis of biologically active compounds
  Supervisor: doc. RNDr. Lenka Kujovská Krčmová, Ph.D.
  Consultant: PharmDr. Pavel Jáč, Ph.D.
• Chromatographic methods coupled to mass spectrometry for bioanalytical purposes
  Supervisor: prof. PharmDr. Lucie Nováková, Ph.D.
• New HPLC and UHPLC methods for clinical research and routine practice
  Supervisor: doc. RNDr. Lenka Kujovská Krčmová, Ph.D.

Bioorganic Chemistry

• Structure-activity relationship study of potential topoisomerase II inhibitors
  Supervisor: doc. PharmDr. Jaroslav Roh, Ph.D.
• Synthesis and study of labeled ultra-long ceramides
  Supervisor: prof. PharmDr. Kateřina Vávrová, Ph.D.
  Consultant: PharmDr. Lukáš Opálka, Ph.D.

Clinical and social pharmacy

• Evaluation of negative outcomes of selected pharmacotherapeutic interventions in seniors in I-CARE4OLD H2020 project
  Supervisor: doc. PharmDr. Daniela Fialová, Ph.D.
• Evaluation of the outcomes of selected nonpharmacological interventions in seniors in I-CARE4OLD H2020 project
  Supervisor: doc. PharmDr. Daniela Fialová, Ph.D.

Pharmaceutical Analysis

• Automated methodologies for analytes of biological and pharmaceutical interest based on luminiscence detection
  Supervisor: doc. PharmDr. Hana Sklenářová, Ph.D.
  Consultant: Dr. Burkhard Horstkotte
• Automation of sample pre-treatment based on extraction procedures using sequential injection analysis IV
  Supervisor: doc. PharmDr. Petr Chocholouš, Ph.D.
• Development of one- and two-dimensional chromatographic methods coupled to mass spectrometry for proteomic analyses and analysis of protein biopharmaceuticals
  Supervisor: doc. PharmDr. Hana Sklenářová, Ph.D.
  Consultant: PharmDr. Juraj Lenčo, Ph.D.

Pharmaceutical Chemistry

• Synthesis and development of new antimicrobial compounds using Computer Aided Drug Design
  Supervisor: doc. PharmDr. Jan Zitko, Ph.D.
• Synthesis and Study of Phthalocyanines for Photodynamic Therapy
  Supervisor: doc. PharmDr. Veronika Nováková, Ph.D.

Pharmaceutical Technology

• (Trans)dermal delivery of active substances using skin permeation enhancers and their effect on healthy and perturbed skin models
  Supervisor: prof. PharmDr. Kateřina Vávrová, Ph.D.
  Consultant: Dr. Georgios Paraskevopoulos, Ph.D.

Pharmacognosy and Nutraceuticals

• Nigella sativa L. alkaloids and their biological activity related to Alzheimer's disease.
  Supervisor: doc. PharmDr. Jakub Chlebek, Ph.D.
• Alkaloids of plant family Amaryllidaceae: isolation, identification, biological activity, preparation of semisynthetic derivatives
  Supervisor: prof. Ing. Lucie Cahlíková, Ph.D.
• Isolation and biological activity of indole alkaloids from South American plants II.
  Supervisor: PharmDr. Marcela Šafratová, Ph.D.

Pharmacology and Toxicology

• Differences in hemocoagulation in patients with metabolic disorders II
  Supervisor: prof. PharmDr. Přemysl Mladěnka, Ph.D.
  Consultant: PharmDr. Alejandro Carazo Fernández, Ph.D.
• Effect of nucleoside-derived antivirals on nucleoside homeostasis and modulation of inflammatory processes in the placenta
  Supervisor: doc. PharmDr. Lukáš Červený, Ph.D.
• Pharmacological and toxicological effects of pollutants on the cardiovascular system
  Supervisor: prof. PharmDr. Přemysl Mladěnka, Ph.D.
  Consultant: PharmDr. Alejandro Carazo Fernández, Ph.D.
• Study of stress-induced senescence in cardiac cells
  Supervisor: prof. PharmDr. Přemysl Mladěnka, Ph.D.
  Consultant: PharmDr. Eduard Jirkovský, Ph.D.
• Study on the role of pharmacokinetic mechanisms in the anticancer drug resistance and possibility of their modulation
  Supervisor: doc. RNDr. Jakub Hofman, Ph.D.

Xenobiochemistry and Pathobiochemistry

• Targeting the resistance in cancer therapy by inhibition of selected human carbonyl reducing enzymes.
  Supervisor: prof. Ing. Vladimír Wsól, Ph.D.