Studies of the pharmacokinetic profiles of drugs with focus on interactions with transport and biotransformation proteins

Group for study of drug resistance and drug interactions

The topic of the Group for study of drug resistance and drug interactions (leader prof. Barbora Szotáková) is drug resistance, mechanisms of its origin and possibilities of its control both in parasitic worms (helminthoresistance) and cancer cells (resistance in anti-cancer therapy).

  • Metabolism of drugs, activity and regulation of drug-metabolizing enzymes and their role in drug interactions and resistance
  • Toxicity and interactions of natural substances/ food supplements with drugs
  • Mechanisms of drug resistance in parasitic helminths
  • The fate of veterinary anthelmintics in the environment

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