At the faculty, teams deal with all aspects of pharmaceuticals, including organic synthesis, medicinal chemistry approaches and structure-activity relationship assessment, biological evaluation based on the monitoring of biotransformation and pharmacodynamics of new molecules, their analysis and evaluation of their stability, formulations of drugs and their targeted application. In the field of natural products, the teams deal with both traditional and newly discovered medicinal plants and their secondary metabolites. Our research also focuses on food supplements of natural origin in terms of their therapeutic or nutritional significance as well as their potential interactions with drugs or other dietary ingredients. Finally, we deal with the analysis of factors influencing therapeutic value, use and consumption of medicines after their introduction into clinical practice.
Research program Development and Study of Drugs (Progres Q42) and PRVOUK
The program is based on a long-term research profile of Faculty of Pharmacy in Hradec Kralove, represents a contionuation of program PRVOUK P40 and includes in particular:
- Syntheses of potential drugs and studies of structure-activity relationships;
- Pharmaceutical analysis of drugs and other biologically active substances including the development and validation of new methods, especially using modern methods of sample preparation;
- Studies of effects of drugs in various experimental pathological states;
- Research in clinical and social pharmacy (analysis of factors influencing therapeutic value, use and consumption of drugs);
- Studies of the pharmacokinetic profiles of drugs with focus on interactions with transport and biotransformation proteins;
- Research of pharmaceutical dosage forms;
- Study of secondary metabolites of pharmaceutically important plants, their biological activity and toxicity.
Research Teams and Workgroups overview