Program

11th European Placental Perfusion Workshop

Hradec Kralove, Czech Republic

29^th May 2018

18.30

Informal dinner, Restaurant Pivovarské domy

30^th May 2018

08.30 – 8.40	Welcome Prof. Dr. Tomáš Šimůnek, PhD., Dean of the Faculty of Pharmacy in Hradec Králové Prof. Dr. František Štaud, PhD., Head of the Department of Pharmacology and Toxicology Assoc. Prof. Dr. Martina Čečková, PhD.
08.40 – 9.00	Keynotes Martina Čečková, Faculty of Pharmacy in Hradec Králové, Czech Republic Title: “Drug interactions with placental transporters”
Drugs in placental perfusions:
09.00 – 09.30	Emilie Hitzerd, Erasmus MC, Rotterdam, Netherlands “The Effect of Sildenafil on the Nitric Oxide Dependent Vasodilation in the Human Placenta; an Ex Vivo Placental Perfusion Study”
09.30 – 10.00	Gaby Eliesen, Radboud University medical center, Nijmegen, Netherlands “Assessing the placental transfer and exposure of TNF inhibitors in women with autoimmune diseases and via an ex vivo placenta perfusion approach”
10.00 – 10.30	Lenka Ťupová, Faculty of Pharmacy in Hradec Králové, Czech Republic “Mechanisms affecting maraviroc transfer across the human placenta, interplay between p-glycoprotein and other transporters”
10.30 – 11.00	Coffee break
11.00 – 11.30	Christian Wadsack, Gruber Michael, Medical Univerzity of Graz, Austria “Interaction of Trastuzumab with the human placental barrier at term”
11.30 – 12.00	Emma Lofthouse, University of Southhampton, United Kingdom “Clearance of glibenclamide from the fetal circulation of the perfused human placenta is enhanced by bromosulphothalein“
12.00 – 12.30	Rona Karahoda, Faculty of Pharmacy in Hradec Králové, Czech Republic “The inhibitory effect of antiretroviral drugs on the L-carnitine uptake in human placenta”
12.30 – 13.30	Lunch
Placental transfer modelling:
13.30 – 14.00	Jolien Freriksen, Radboud University medical center, Nijmegen, Netherlands “Assessment of maternal and fetal dolutegravir exposure by integrating ex vivo placental perfusion data and physiologically-based pharmacokinetic modeling“
14.00 – 14.30	Bram Sengers, University of Southhampton, United Kingdom “Computational modelling of placental transfer as an integrated system“
14.30 – 15.00	Coffee break
Methodology improving:
15.00 – 15.30	Gareth Nye, University of Manchester, United Kingdom “Utilising both ex vivo dual perfusion and a novel unidirectional human placental perfusion chamber to assess placental oxygen levels, transfer and consumption in the intervillous space“
15.30 – 16.30	Technical notes, interactive discussion
Social events:
17.00 – 19.00	Guided city tour, Velké náměstí, Hradec Králové
19.00 – 23.00	Social dinner, Šatlava Restaurant

31^st May 2018

Placental physiology
08.30 – 9.00	Birgit Hischmugl, Medical University of Graz “Placental lipid stores are mobilised by the intracellular acting monoacylglycerol lipase“
9.00 – 9.30	Isabella Ellinger, Medical University of Vienna, Austria “Human neonatal fc receptor (hfcrn) is expressed in placental endothelial cells, the second cell layer of the placental barrier“
09.30 – 10.00	Frantisek Staud, Faculty of Pharmacy in Hradec Králové, Czech Republic “Placental metabolism of tryptophan in health and disease“
Nanoparticles and placental microvesicles
10.00 – 10.30	Tina Bürki-Thurnherr, Empa, St. Gallen, Switzerland “Gene expression profiling of an ex vivo human placenta perfusion model following exposure to engineered nanomaterials”
10.30 – 11.00	Leonie Aengenheister, Empa, St. Gallen, Switzerland “Investigation of surface modification dependent placental uptake, accumulation and translocation of gold nanoparticles using human in vitro and ex vivo models”
11.00 – 11.30	Coffee break
11.30 – 12.15	Rodolfo Favaro, University hospital Jena, Germany “The one-sided ex vivo placenta perfusion as a model for the isolation of RNA from trophoblastic extracellular vesicles” Udo Markert, University hospital Jena, Germany “Trophoblast-T cell communication via miRNAs transported in extracellular vesicles”
12.15 – 12.45	Rohan Lewis, University of Southhampton, United Kingdom “3D Imaging of placental microvesicles forming on the tips of microvilli“
12.45 – 13.00	Discussion on the next EPPW
13.00 – 14.00	Lunch, end of the workshop

Program

11th European Placental Perfusion Workshop

29th May 2018

30th May 2018

Drugs in placental perfusions:

Placental transfer modelling:

Methodology improving:

Social events:

31st May 2018

Placental physiology

Nanoparticles and placental microvesicles

29^th May 2018

30^th May 2018

31^st May 2018