Doctoral Dissertation Themes

List of doctoral dissertation themes for the academic year 2026/2027

Applied physics and mathematics in medicine and pharmacy

• Chemical reactions during drug metabolism
  Supervisor: Eugen Hruška, Ph.D.
• Integrating mathematical modeling and experimental approaches in in vitro biology
  Supervisor: Mgr. Veronika Bernhauerová, Ph.D.
• The preparation of biologically active ligands labeled with selected radionuclides for radiotherapeutical anticancer application
  Supervisor: doc. Mgr. Pavel Bárta, Ph.D.

Bioanalytical Methods

• Chromatographic methods coupled to mass spectrometry for bioanalytical purposes
  Supervisor: prof. PharmDr. Lucie Nováková, Ph.D.
• Development of automated syringe-based sample preparation methodologies exploiting novel hardware modalities
  Supervisor: doc. Burkhard Horstkotte, M.Sc., Dr.
  Consultant: doc. PharmDr. Hana Sklenářová, Ph.D.
• New HPLC and UHPLC methods for clinical research and routine practice
  Supervisor: doc. RNDr. Lenka Kujovská Krčmová, Ph.D.
• The use of advanced analytical techniques for detection and determination of contaminants in food and environmental samples
  Supervisor: prof. RNDr. Dalibor Šatínský, Ph.D.

Bioorganic Chemistry

• Covalently anchored lipids as a new paradigm of biological matter: synthetic and biophysical reconstruction of architecturally programmed membrane asymmetry
  Supervisor: doc. PharmDr. Lukáš Opálka, Ph.D.
• Membrane remodeling beyond bilayers: emergence of covalently anchored multilamellar architectures in the human skin barrier
  Supervisor: doc. PharmDr. Lukáš Opálka, Ph.D.
• Photoactivatable lipids to uncover hidden coupling between antimicrobial peptides and the skin permeability barrier
  Supervisor: doc. PharmDr. Lukáš Opálka, Ph.D.
• Sphingolipids as Chemical Tools for Studying the Function of the Skin Barrier in Health and Disease
  Supervisor: doc. PharmDr. Lukáš Opálka, Ph.D.

Clinical and social pharmacy

• Agonist Pharmacotherapy in the Treatment of Stimulant Use Disorder with a Focus on Methamphetamine in the Czech Republic
  Supervisor: prof. PharmDr. Petr Nachtigal, Ph.D.
  Consultant: Mgr. Zuzana Svobodová, Ph.D.
• Non-Pharmacological Interventions for Chronic Disease Management and Health Promotion
  Supervisor: doc. PharmDr. Jitka Pokladníková, Ph.D.

Pharmaceutical Analysis

• Automated methodologies for analytes of biological and pharmaceutical interest based on luminiscence detection
  Supervisor: doc. PharmDr. Hana Sklenářová, Ph.D.
  Consultant: doc. Burkhard Horstkotte, M.Sc., Dr.
• Automated sample preparation strategies for separation techniques
  Supervisor: doc. Burkhard Horstkotte, M.Sc., Dr.
  Consultant: doc. PharmDr. Hana Sklenářová, Ph.D.
• Generic HPLC middle-up analyses of antibody biopharmaceuticals
  Supervisor: doc. PharmDr. Juraj Lenčo, Ph.D.
• Multidimensional methods for analysis of pharmaceutical and bioanalytical samples based on automated extraction procedures and high-performance liquid chromatography
  Supervisor: doc. PharmDr. Petr Chocholouš, Ph.D.

Pharmaceutical Chemistry

• Synthesis and study photosensitizers for photodynamic therapy
  Supervisor: doc. PharmDr. Veronika Nováková, Ph.D.

Pharmaceutical Technology

• Study of interactions in drug delivery systems based on mesoporous silica
  Supervisor: doc. PharmDr. Barbora Vraníková, Ph.D.
• Study of topically administered pharmaceutically/cosmetically relevant substances on skin lipid barrier microstructure and function using model systems
  Supervisor: doc. PharmDr. Andrej Kováčik, Ph.D.

Pharmacognosy and Nutraceuticals

• Arundo donax L. alkaloids and their biological activity.
  Supervisor: doc. PharmDr. Jakub Chlebek, Ph.D.
• Biological activity of Amaryllidaceae alkaloids and their semisynthetic derivatives in connection with Alzheimer´s disease
  Supervisor: prof. Ing. Lucie Cahlíková, Ph.D.

Pharmacology and Toxicology

• Perspectives in nuclear receptors modulation with novel approaches (small molecules, allosteric modulators or degraders)
  Supervisor: prof. PharmDr. Petr Pávek, Ph.D.
• Pharmacology of reproductive system
  Supervisor: prof. PharmDr. František Štaud, Ph.D.
• Study on the role of pharmacokinetic mechanisms in anticancer drug resistance and the possibility of their pharmacological modulation
  Supervisor: doc. RNDr. Jakub Hofman, Ph.D.

Xenobiochemistry and Pathobiochemistry

• Epigenetic regulation of carbonyl-reducing enzymes in parasitic nematodes
  Supervisor: doc. Ing. Petra Matoušková, Ph.D.
• Human Aldo-Keto Reductases in Breast Tumors and Their Contribution to Drug Resistance.
  Supervisor: prof. Ing. Vladimír Wsól, Ph.D.