Granty a projekty

Pokročilé topické transportní systémy kombinující dendrimery a liposomy

Topical dermal delivery is an effective way of delivering drugs to targeted skin layers. As the skin is an excellent barrier, mainly due to the stratum corneum, numerous penetration strategies have been utilized to overcome this delivery obstacle. Nanocarriers have gained considerable interest as alternative drug delivery strategies, on account of improved penetration and delivery of drugs into specific skin regions. Skin Cancer is a major health problem with rising incidences worldwide, requiring improved therapies with fewer side effects. The aim of this project is to design an innovative combination of drug delivery nanosystems as an effective and safe skin delivery system of anticancer drugs. More specifically, new lower generation dendrimers will be synthesized, having the structural characteristics which proved to be beneficial for skin drug delivery. These dendrimers will be complexed with anti-cancer drugs and the complex will be loaded in liposomes. The new liposomal/dendrimer drug delivery system will be characterized and evaluated for its ability to effectively and specifically deliver its cargo to the human epidermis ex vivo.

Číslo: GAUK274221

Období: 01.01.2021 - 31.12.2022

Poskytovatel: Univerzita Karlova - Grantová agentura UK

Hlavní řešitel: Panoutsopoulou Eleni - Farmaceutická fakulta v Hradci Králové

Celkový objem financí: 524 000,00 Kč

Interní řešitelé

Hlavní řešitel: Eleni Panoutsopoulou - Farmaceutická fakulta v Hradci Králové, FaF HK
Spoluřešitel: Irene Sagrafena - Farmaceutická fakulta v Hradci Králové, FaF HK
Spoluřešitel: Tereza Stehlíková - Farmaceutická fakulta v Hradci Králové, FaF HK
Spoluřešitel: Panagiota Velissari - Farmaceutická fakulta v Hradci Králové, FaF HK
Spoluřešitel: Martin Škarda - Farmaceutická fakulta v Hradci Králové, FaF HK
Školitel: doc. Dr. rer. nat. Mgr. Jarmila Zbytovská - Univerzita Karlova,

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