Selected methods of pharmaceutical technology

The subject enables students interested in the employment in pharmaceutical industry to get more profound theoretical and practical knowledge in the field of some of the specialized manufacturing and control procedures of pharmaceutical technology. The methods included in the subject are related to the evaluation of incoming raw materials, preparation of intermediate products, or manufacture of final medicinal preparations and their evaluation. The orientation of the subject links up with other subjects enabling specialization of students for pharmaceutical technology.


  • Differential scan calorimetry (DSC)
    • characterization of  biodegradable polymers by DSC (determination of glass transition temperature Tg)
    • polymers plasticization
    • influence of the plasticizer type and concentration on Tg
    • drug incorporation into the polymer (fusion method, plasticization method, solvent method)
    • thermal analyses of solid polymeric dispersions
  • Pycnometric density of solids, porosimetry
    • determination of tablet´s excipients density
    • determination of tableting materials density
    • determination of density and porosity of tablets in dependence on compression pressure
  • Determination of surface tension of liquids
    • determination of surface tension of water
    • determination of surface tension of surfactant solutions (cationic, anionic and nonionic)
  • Rheological evaluation of pharmaceutical preparations
    • analysis of rheogram by appropriate models
    • characterization of  semi-solid preparations by Herschel-Bulkely model (coefficient of consistency and flow behaviour)
    • thixotropy characterization of the pharmaceutical preparations
    • influence of the pharmaceutical preparations composition and technology of compounding on rheological characteristics
  • Fluid bed granulation
    • influence of process parameters on the quality of  granulates
    • preparing of a granulate and its evaluation
  • Spray drying
    • influence of process parameters on the quality of a dried product
    • evaluation of the spray dried product
  • Evaluation of the compressibility of tabletting materials and the effect of lubricants
    • evaluation of the energetic profile of dry binders and directly compressible tabletting materials
    • evaluation of the compactibility of dry binders and directly compressible tabletting materials by tensile strength of tablets
    • evaluation of the lubricant effect in tabletting materials
  • Dissolution tests
    • determination of active ingredients dissolution profile released from prolonged release tablets
    • comparison of basket, paddle and flow- through cell dissolution methods
    • influence of dissolution test´s settings on dissolution profiles


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