Pharmaceutical Chemistry

Pharmaceutical Chemistry is a specific pharmaceutical subject representing the link between chemical and biological disciplines. Its task is to provide students with a complex understanding of drug and auxiliary substance chemistry. The drugs are studied from the point of view of their rational selection and preparation, quality criteria, suitable ways of storage, structure-activity and structure-metabolism relationships, and practical usage. The brief information concerning mechanisms of drug action covered in this subject forms the basis for a more profound study of this topic in pharmacology. This subject belongs to the state final examination group of subjects.

Syllabus

Definition and characterization of the subject

Historical development of pharmaceutical chemistry

Sources of new drugs

Drug nomenclature

Structural factors affecting biological activity

Drug structure modifications

Physicochemical properties in relation to biological activity

Drugs affecting the central nervous system:

  • General anesthetics
  • Sedative-hypnotics
  • Anticonvulsants
  • Neuroleptics
  • Anxiolytics
  • Antidepressants
  • Psychostimulants
  • Hallucinogens
  • Antiparkinsonian agents
  • Opiate analgesics
  • Nonopiate analgesics
  • Nonsteroidal anti-inflammatory agents
  • Antiemetics
  • Antitussives
  • Expectorants

Drugs affecting the peripheral nervous system

  • Local anesthetics
  • Skeletal muscle relaxants

Drugs affecting the autonomic nervous system

  • Adrenergic agents
  • Antiadrenergic agents
  • Cholinergic agents
  • Anticholinergic and antispasmodic agents

Histamine and antihistamines

Drugs affecting blood and the cardiovascular system

  • Anti-arrythmic agents
  • Anticoagulants
  • Antihyperlipidemics
  • Cardiac glycosides
  • Antihypertensive agents
  • Vasodilatators
  • Plasma extenders

Drugs affecting the gastrointestinal tract and kidney

  • Drugs influencing gastric acidity
  • Adsorbents
  • Oral antidiabetic agents
  • Laxatives
  • Diuretics

Vitamines

Hormones

  • Peptide and protein hormones
  • Sex hormones and analogs
  • Corticoids
  • Prostaglandins

Antiinfective and antiinvasive agents

  • Antiseptics and disinfectants
  • Antifungal agents
  • Antiprotozoals
  • Antimalarials
  • Synthetic antibacterial agents (sulfanilamides, quinolones)
  • Antibiotics
  • Antimycobacterial agents
  • Anthelmintics
  • Antivirals
  • Antineoplastic agents

 

Seminars

Selected topics are discussed in more detailed manner

 

Practical Training

  • Study of relationships between physicochemical properties and biological potencies of drugs (solubility in water, solubility in lipids, log P calculations, acidobasic properties, adsorption etc.)
  • Study of relationships between steric arrangement and biological activities of drugs (modelling of representative types of drugs - hybridization of carbon atom, conformation, geometric and optical isomerism, configuration)
  • Syntheses of drugs (basic types of drugs, for example paracetamol, acetylsalicylic acid, analogues of benzocain etc.)
  • Practical working with basic chemical literature with special view of the Pharmaceutical Chemistry (Beilstein's Handbuch der organischen Chemie, Chemical Abstracts, International Pharmaceutical Abstracts, patent literature, Pharmazeutische Stoffliste, scientific journals etc.)

Literature

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