Immunology

Students become acquainted with the structure and functions of human immune system in health and disease.

Syllabus

  • The structure of the immune system: cells, lymphoid organs, lymphatic vessels
  • Ontogeny and phylogeny of immunity
  • Antigens, molecules recognizing antigens specifically, immunoglobulins, the generation of diversity of antibodies, T-cell antigen receptors
  • Major histocompatibility complex, immunogenetics
  • Antigen-antibody reaction, basic immunochemistry, principles of serology
  • Adaptive immunity, immunological memory, immunity to microbes; principles of vaccination
  • Antitumour immunity, mechanisms of graft rejection
  • Immunological tolerance
  • Innate immunity: phagocytosis, complement, inflammation.
  • Regulation in the immune system, co-operation of cells of immune system, cytokine network, the role of the immune system in homeostasis
  • Immunopathology: allergy and hypersensitivity, autoimmune diseases, immunodeficiency, AIDS
  • Principles of immunological methods, their application in pharmacy
  • Immunoglobulins, molecules specifically recognizing antigen, Jerne’s theory of idiotype – antiidiotype network
  • Immunonological memory, principles of vaccines
  • Introduction in the laboratory methods like: testing of phagocytic activity, assays for estimation of complement activity, assessment of lysozyme and C-reactive protein, precipitation in gels, immunoelectrophoresis, basic serological tests, immunoenzymatic and immunofluorescence assays, MHC matching, flow cytometry

Literature

  • Jilek P.: Basic Immunology, internal publication of Faculty of Pharmacy on intranet, 2008, 62 pp.
  • Sompayarac L.: How the immune system works. 4rd edition. Willey Blackwell, ISBN-13: 978-0470657294 2012, 141 pp.

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