Members of the Skin Barrier Research Group published a paper in the Journal of Investigative Dermatology, showing that acidic pH is a critical factor in forming skin lipid barrier.
The article authored by Anna Nováčková, Irene Sagrafena, Petra Pullmannová, Georgios Paraskevopoulos, Anupma Dwivedi, Anisha Mazumder, Karolína Růžičková, Petr Slepička, Jarmila Zbytovská, and Kateřina Vávrová, titled Acidic pH is Required for the Multilamellar Assembly of Skin Barrier Lipids in Vitro revealed yet another function of the skin´s “acid mantle”. Apart from regulating enzyme activities and keeping away pathogens, the acidic pH induces changes in lipid shape and mixing, resulting in a functional lipid barrier that protects our body from excessive water loss.
The Journal of Investigative Dermatology is among the top journals in dermatology, with an impact factor of 7.1 (D1, AIS 2.1).
This work was supported by the Czech Science Foundation (19-09135J), Charles University (GAUK 1156120 and SVV 260547), EFSA-CDN (No. CZ.02.1.01/0.0/0.0/16_019/0000841 co-funded by ERDF), and InoMed (No. CZ.02.1.01/0.0/0.0/18_069/0010046 co-funded by the European Union).
Text: prof. PharmDr. Kateřina Vávrová, Ph.D.
Photo: Skin Barrier Research Group