The results of the experimental work of the Research group for the study of drug resistance and drug interactions were published in the journal Veterinary Research, which ranks fourth out of 142 journals in the field of Veterinary science in the WoS evaluation according to the Article Influence Score (AIS). According to the Impact factor, the journal also belongs to the first decile of this field.
The research group has long been engaged in study of the mechanisms of drug resistance in parasites. A newly published results showed that contact of parasitic nematodes with sublethal doses of the anthelmintic drug albendazole (e.g. during incorrect dosing) induces drug metabolizing enzymes (especially UDP-glycosyltransferases and ABC transporters). By this way the parasites acquire ability to more effectively inactivate albendazole in subsequent contact. The doctoral student Mgr. Pavlína Kellerová is the first and the most important author of this publication. We congratulate her and wish many successes in further study.
Text: prof. RNDr. Lenka Skálová, Ph.D. and doc. PharmDr. Jaroslav Roh, Ph.D.
Photo: Group for study of drug resistance and drug interactions