Members of the Skin Barrier Research Group published in Angewandte Chemie, a journal with an impact factor of 12.3, for showing a new fundamental aspect of the skin barrier lipids.
The article authored by O. Engberg, A. Kováčik, P. Pullmannová, M. Juhaščik, L. Opálka, D. Huster and K. Vávrová titled “The Sphingosine and Acyl Chains of Ceramide [NS] Show Very Different Structure and Dynamics Challenging Our Understanding of the Skin Barrier” is a result of a collaboration of prof. Kateřina Vávrová´s group with prof. Daniel Huster´s group from the Institute of Medical Physics and Biophysics, the University of Leipzig.
Dynamic chains in a rigid matrix. While originally assumed to be fully rigid, our spectroscopic data reveals that sphingosine chains of ceramide molecules in the outermost human skin layer exhibit a comprehensive dynamical behavior allowing to fine tune our understanding of the molecular details of the skin barrier.
This work was supported by the Czech Science Foundation and German Research Foundation (19-09135J and HU 720 18/1) and the project EFSA-CDN (No. CZ.02.1.01/0.0/0.0/16_019/0000841) co-funded by ERDF.
Text: doc. PharmDr. Jaroslav Roh, Ph.D., Vice-Dean for Scientific Activity, Doctoral Studies and Technology Transfer
Pictures: Archive of the Skin Barrier Research Group