Programme of the NETPHARM conference

 

Conference of the NETPHARM project

14th – 15th April 2025, Hradec Králové

Venue

Hotel and congress center Nové Adalbertinum, Hradec Králové, Czech Republic

14th April 2025 / Monday

09:30–10:00     Registration & Welcome Coffee break
10:00–10:05 Jaroslav Roh FoP CU Opening & Welcome Remarks
10:05–10:15 Petr Pávek FoP CU NETPHARM conference overview
10:15–10:40 Pavel Plevka MU CEITEC Plenary Lecture: Using cryo-EM and cryo-ET to study native and pathological cell processes

WP1

Pharmaceutical and analytical chemistry

Chairperson: Kateřina Vávrová
10:40–10:45 Kateřina Vávrová FoP CU Short introduction of WP1
10:45–10:50 Petr Zimčík FoP CU Research of photoactive compounds
10:50–10:55 Kateřina Vávrová FoP CU Molecular organisation of the skin lipid barrier and prospects for lipid-based therapies
10:55–11:15 Milan Vrábel IOCB From click chemistry to dendralenes: Integrative approaches in modern chemical synthesis and drug development
11:15–11:35 Lucie Nováková FoP CU Use of artificial neural networks in SFC-MS method development
11:35–11:40 Radim Nencka IOCB Methyltransferase inhibitors as potential therapeutics
11:40–11:55 Andrea Brancale UCT The Struggle and Promise of Drugging Difficult Targets
11:55–12:00 Jaroslav Roh FoP CU Design, synthesis and structure-activity relationships of potential topoisomerase II inhibitors
12:00–12:05 Lucie Cahlíková FoP CU Minor secondary metabolites of plants as inspiration for medicinal chemistry
12:05–12:15     Discussion
12:15–13:15     Lunch (Lunch will be provided)

WP2

Pharmacology and toxicology

Chairperson: František Štaud
13:15–13:20 František Štaud FoP CU Short introduction of WP2
13:20–13:30 Přemysl Mladěnka FoP CU Platelet aggregation in diabetes mellitus: data from patients and simulation of diabetic conditions ex vivo
13:30–13:40 Tomáš Šimůnek FoP CU Targeting a new druggable site on topoisomerase II for isoform-selective inhibition and prevention of anthracycline cardiotoxicity
13:40–14:00 Lukáš Červený FoP CU Testing prenatal toxicity using placenta-derived models 
14:00–14:20 Petr Pávek, 
Petr Nachtigal
FoP CU New insights in liver and metabolic diseases
14:20–14:40 Jakub Hofman FoP CU Drug-drug interactions and their potential in modulating pharmacokinetic resistance
14:40–14:50     Discussion
14:50–15:00     Short Break
15:00–15:20 Jiří Demuth FoP CU Open Science principles, Open Access publications, Data management plan
15:20–15:40     Coffee Break

WP4

Optimization of pharmacotherapy in older patients: interdisciplinary cooperation of clinical pharmacists, geriatricians and nephrologists

Chairperson: Daniela Fialová
15:40–15:45 Daniela Fialová FoP CU Short introduction of WP4
15:45–16:00 Daniela Fialová FoP CU The need for novel principles of individualization of drug schemes in older adults: scientific works on the WP4 of the Netpharm project
16:00–16:15 Sylvie Sulková-Dusilová FoM CU Cardio-renal syndrome and optimization of pharmacotherapy in older age - selection of the recent information from the systematic literature search
16:15–16:30 Eva Topinková FoM CU Geriatric frailty syndrome – need for an individualized pharmacotherapy. Findings from the systematic literature search
16:30–16:40     Discussion
16:40–17:00   All Networking disscusion, Poster presentation
17:00–18:30     Social event – Guided tour of the landmark Bílá věž; White Tower (optional, at participant's expense)
18:30–20:00     Networking dinner (Dinner will be provided)
20:00–22:00   All Poster presentation

 

15th April 2025 / Tuesday

9:00–9:05 Petr Pávek FoP CU Opening
9:05–9:15 ISAB introduction
  Maria da Conceição Montenegro University of Porto, Portugal
  Michael Lämmerhofer University of Tübingen, Germany
  Kevin A. Schug University of Texas at Arlington, USA
  Igor Lacík Polymer Institute of the Slovak Academy of Sciences, Slovakia
  Søren Bak University of Copenhagen, Denmark
  Francisco A. Macías University of Cádiz, Spain
9:159:40 Evžen Bouřa IOCB Plenary Lecture: Structure-based inhibitor design 

WP3

Novel drug delivery systems and formulations

Chairperson: Martin Hrubý
9:40–9:45 Martin Hrubý IMC Short introduction of WP3 
9:459:55 Martin Hrubý IMC Reactive oxygen species – responsive poly(2-alkyl-2-oxazoline)-containing polymer systems for theranostics and sensing
9:5510:10 František Štěpánek UCT Mass customization: A novel manufacturing concept for special patient groups
10:1010:25 Ondřej Holas FoP CU Overcoming Biological Barriers: Development of Precision Drug Delivery
10:25–10:45     Coffee Break
10:4511:00 Jarmila Zbytovská UCT Nanoparticles for topical drug delivery
11:0011:15 Miroslav Šoóš UCT Screening, characterization and formulation of new drug solid forms with improved properties
11:15–11:25     Discussion

WP5

Advanced in vitro and in silico methods and drug development

Chairperson: Tomáš Smutný
11:25–11:30 Tomáš Smutný FoP CU Short introduction of WP5
11:3011:40 Tomáš Smutný FoP CU Rifampicin and its derivatives: stability, disposition, and affinity towards pregnane X receptor employing 2D and 3D primary human hepatocytes
11:4011:50 Veronika Bernhauerová FoP CU Quantifying expression and metabolic activity of genes regulated by pregnane X receptor in primary human hepatocyte spheroids
11:5012:00 Petra Matoušková FoP CU Benzhydroxamic acid derivative as a new nematocidal drug with a novel target
12:00–12:10     Discussion
12:10–12:15 Petr Pávek FoP CU Poster Awards
12:15–13:15     Lunch (Lunch will be provided)
13:1513:30 PB, Managers All Project Board meeting
13:3014:00 Managers All Project managers´ meeting
13:3014:30 Awarded JRs All Best Awarded poster presentations
14:30–15:30     Coffee Break
15:30–16:00 Transfer   Transfer to Charles University, Faculty of Pharmacy, Akademika Heyrovskeho 1203, Hradec Kralove
16:0017:20 Demonstration of instruments All New research infrastructure of the NETPHARM project - practical demonstration of new research facilities
17:20–17:30 Petr Pávek FoP CU Closing Remarks  & Closing of the conference
17:30–18:00 Transfer   Transfer from Charles University, Faculty of Pharmacy to the city center 
18:30 ISAB, PB   Networking dinner (ISAB + Project Board) - Pivovarské domy, Velké náměstí 26, Hradec Králové

 

*Charles University (CU) – Faculty of Pharmacy in Hradec Králové (FoP CU), Faculty of Medicine in Hradec Králové (FoM CU), University of Chemistry and Technology, Prague (UCT), Masaryk University (MU) – Central European Institute of Technology Masaryk university (CEITEC), ISAB - International Scientific Advisory Board

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