Conference of the NETPHARM project
14th – 15th April 2025, Hradec Králové
Venue
Hotel and congress center Nové Adalbertinum, Hradec Králové, Czech Republic
14th April 2025 / Monday
| 09:30–10:00 |
|
|
Registration & Welcome Coffee break |
| 10:00–10:05 |
Jaroslav Roh |
FoP CU |
Opening & Welcome Remarks |
| 10:05–10:15 |
Petr Pávek |
FoP CU |
NETPHARM conference overview |
| 10:15–10:40 |
Pavel Plevka |
MU CEITEC |
Plenary Lecture: Using cryo-EM and cryo-ET to study native and pathological cell processes |
WP1
|
Pharmaceutical and analytical chemistry
|
| Chairperson: |
Kateřina Vávrová |
| 10:40–10:45 |
Kateřina Vávrová |
FoP CU |
Short introduction of WP1 |
| 10:45–10:50 |
Petr Zimčík |
FoP CU |
Research of photoactive compounds |
| 10:50–10:55 |
Kateřina Vávrová |
FoP CU |
Molecular organisation of the skin lipid barrier and prospects for lipid-based therapies |
| 10:55–11:15 |
Milan Vrábel |
IOCB |
From click chemistry to dendralenes: Integrative approaches in modern chemical synthesis and drug development |
| 11:15–11:35 |
Lucie Nováková |
FoP CU |
Use of artificial neural networks in SFC-MS method development |
| 11:35–11:40 |
Radim Nencka |
IOCB |
Methyltransferase inhibitors as potential therapeutics |
| 11:40–11:55 |
Andrea Brancale |
UCT |
The Struggle and Promise of Drugging Difficult Targets |
| 11:55–12:00 |
Jaroslav Roh |
FoP CU |
Design, synthesis and structure-activity relationships of potential topoisomerase II inhibitors |
| 12:00–12:05 |
Lucie Cahlíková |
FoP CU |
Minor secondary metabolites of plants as inspiration for medicinal chemistry |
| 12:05–12:15 |
|
|
Discussion |
| 12:15–13:15 |
|
|
Lunch (Lunch will be provided) |
WP2
|
Pharmacology and toxicology
|
| Chairperson: |
František Štaud |
| 13:15–13:20 |
František Štaud |
FoP CU |
Short introduction of WP2 |
| 13:20–13:30 |
Přemysl Mladěnka |
FoP CU |
Platelet aggregation in diabetes mellitus: data from patients and simulation of diabetic conditions ex vivo |
| 13:30–13:40 |
Tomáš Šimůnek |
FoP CU |
Targeting a new druggable site on topoisomerase II for isoform-selective inhibition and prevention of anthracycline cardiotoxicity |
| 13:40–14:00 |
Lukáš Červený |
FoP CU |
Testing prenatal toxicity using placenta-derived models |
| 14:00–14:20 |
Petr Pávek,
Petr Nachtigal |
FoP CU |
New insights in liver and metabolic diseases |
| 14:20–14:40 |
Jakub Hofman |
FoP CU |
Drug-drug interactions and their potential in modulating pharmacokinetic resistance |
| 14:40–14:50 |
|
|
Discussion |
| 14:50–15:00 |
|
|
Short Break |
| 15:00–15:20 |
Jiří Demuth |
FoP CU |
Open Science principles, Open Access publications, Data management plan |
| 15:20–15:40 |
|
|
Coffee Break |
WP4
|
Optimization of pharmacotherapy in older patients: interdisciplinary cooperation of clinical pharmacists, geriatricians and nephrologists
|
| Chairperson: |
Daniela Fialová |
| 15:40–15:45 |
Daniela Fialová |
FoP CU |
Short introduction of WP4 |
| 15:45–16:00 |
Daniela Fialová |
FoP CU |
The need for novel principles of individualization of drug schemes in older adults: scientific works on the WP4 of the Netpharm project |
| 16:00–16:15 |
Sylvie Sulková-Dusilová |
FoM CU |
Cardio-renal syndrome and optimization of pharmacotherapy in older age - selection of the recent information from the systematic literature search |
| 16:15–16:30 |
Eva Topinková |
FoM CU |
Geriatric frailty syndrome – need for an individualized pharmacotherapy. Findings from the systematic literature search |
| 16:30–16:40 |
|
|
Discussion |
| 16:40–17:00 |
|
All |
Networking disscusion, Poster presentation |
| 17:00–18:30 |
|
|
Social event – Guided tour of the landmark Bílá věž; White Tower (optional, at participant's expense) |
| 18:30–20:00 |
|
|
Networking dinner (Dinner will be provided) |
| 20:00–22:00 |
|
All |
Poster presentation |
15th April 2025 / Tuesday
| 9:00–9:05 |
Petr Pávek |
FoP CU |
Opening |
| 9:05–9:15 |
ISAB introduction |
| |
Maria da Conceição Montenegro |
University of Porto, Portugal |
| |
Michael Lämmerhofer |
University of Tübingen, Germany |
| |
Kevin A. Schug |
University of Texas at Arlington, USA |
| |
Igor Lacík |
Polymer Institute of the Slovak Academy of Sciences, Slovakia |
| |
Søren Bak |
University of Copenhagen, Denmark |
| |
Francisco A. Macías |
University of Cádiz, Spain |
| 9:15–9:40 |
Evžen Bouřa |
IOCB |
Plenary Lecture: Structure-based inhibitor design |
WP3
|
Novel drug delivery systems and formulations
|
| Chairperson: |
Martin Hrubý |
| 9:40–9:45 |
Martin Hrubý |
IMC |
Short introduction of WP3 |
| 9:45–9:55 |
Martin Hrubý |
IMC |
Reactive oxygen species – responsive poly(2-alkyl-2-oxazoline)-containing polymer systems for theranostics and sensing |
| 9:55–10:10 |
František Štěpánek |
UCT |
Mass customization: A novel manufacturing concept for special patient groups |
| 10:10–10:25 |
Ondřej Holas |
FoP CU |
Overcoming Biological Barriers: Development of Precision Drug Delivery |
| 10:25–10:45 |
|
|
Coffee Break |
| 10:45–11:00 |
Jarmila Zbytovská |
UCT |
Nanoparticles for topical drug delivery |
| 11:00–11:15 |
Miroslav Šoóš |
UCT |
Screening, characterization and formulation of new drug solid forms with improved properties |
| 11:15–11:25 |
|
|
Discussion |
WP5
|
Advanced in vitro and in silico methods and drug development
|
| Chairperson: |
Tomáš Smutný |
| 11:25–11:30 |
Tomáš Smutný |
FoP CU |
Short introduction of WP5 |
| 11:30–11:40 |
Tomáš Smutný |
FoP CU |
Rifampicin and its derivatives: stability, disposition, and affinity towards pregnane X receptor employing 2D and 3D primary human hepatocytes |
| 11:40–11:50 |
Veronika Bernhauerová |
FoP CU |
Quantifying expression and metabolic activity of genes regulated by pregnane X receptor in primary human hepatocyte spheroids |
| 11:50–12:00 |
Petra Matoušková |
FoP CU |
Benzhydroxamic acid derivative as a new nematocidal drug with a novel target |
| 12:00–12:10 |
|
|
Discussion |
| 12:10–12:15 |
Petr Pávek |
FoP CU |
Poster Awards |
| 12:15–13:15 |
|
|
Lunch (Lunch will be provided) |
| 13:15–13:30 |
PB, Managers |
All |
Project Board meeting |
| 13:30–14:00 |
Managers |
All |
Project managers´ meeting |
| 13:30–14:30 |
Awarded JRs |
All |
Best Awarded poster presentations |
| 14:30–15:30 |
|
|
Coffee Break |
| 15:30–16:00 |
Transfer |
|
Transfer to Charles University, Faculty of Pharmacy, Akademika Heyrovskeho 1203, Hradec Kralove |
| 16:00–17:20 |
Demonstration of instruments |
All |
New research infrastructure of the NETPHARM project - practical demonstration of new research facilities |
| 17:20–17:30 |
Petr Pávek |
FoP CU |
Closing Remarks & Closing of the conference |
| 17:30–18:00 |
Transfer |
|
Transfer from Charles University, Faculty of Pharmacy to the city center |
| 18:30 |
ISAB, PB |
|
Networking dinner (ISAB + Project Board) - Pivovarské domy, Velké náměstí 26, Hradec Králové |
*Charles University (CU) – Faculty of Pharmacy in Hradec Králové (FoP CU), Faculty of Medicine in Hradec Králové (FoM CU), University of Chemistry and Technology, Prague (UCT), Masaryk University (MU) – Central European Institute of Technology Masaryk university (CEITEC), ISAB - International Scientific Advisory Board