Doctoral Dissertation Themes

Development and application of LC-MS method for analysis of biopharmaceuticals I.

The work will be based on development and evaluation of LC-MS methods using conventional analytical chromatograph for identification and quantitation of peptides and proteins with the aim to reach sensitivity comparable with nanoLC-MS methods. The main analytical technique will be UHPLC chromatography coupled with mass spectrometry with high resolution. Methods will be applied for qualitative and quantitative analysis of biopharmaceuticals.

Supervisor: doc. PharmDr. Hana Sklenářová, Ph.D.

Keywords: identification, quantitation, peptides, proteines

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