Program

Conference program

( PDF version of program )


Short lectures marked with red asterisk * will be presented in Czech/Slovak language. Other lectures will be presented in English language.

Tuesday 3. 2. 2015, Lecture Hall A 

8:20  Opening of the conference – Doc. PharmDr. Tomáš Šimůnek, Ph.D., dean of the faculty
8:30

Plenary lecture
Continuing the exploration of in-syringe stirring: Applications beyond dispersive liquid-liquid micro-extraction
Horstkotte B., Chocholouš P., Bešťák O., Solich P.

 

Bioorganic and Pharmaceutical Chemistry Section

Chairman: Prof. RNDr. Milan Pour, Ph.D.; Prof. PharmDr. Martin Doležal, Ph.D.;
Doc. PharmDr. Petr Zimčík, Ph.D.

9:00

Keynote lecture
Studies towards the Synthesis of Morphine Precursor
Ghavre M., Varghese V., Hudlický T.

9:30

Computational approach to search for novel antituberculostics
Holas O., Slovák F., Doležal M.

Synthesis of novel α,β-diphenyl furanones as potential antitumorous and antimicrobial agents
Horký P., Voráčová M., Vacek J., Pour M.

Novel ABAD Modulators for Modifying Treatment of Alzheimer’s disease
Hroch L., Benek O., Aitken L., Gunn-Moore F., Musilek K.

10:20-10:35  Coffee break (room S2155)
 

Preparation of quinazoline compounds with bronchodilatory activity
Hrušková Z.R., Ježková V., Vopršálová M., Špulák M.

Preparation and biological evaluation of novel pyrazinamide derivatives synthesized under microwave conditions
Jandourek O., Paterova P., Kralova K., Dolezal M.

Drug design and development of novel drugs for Alzheimer’s disease treatment
Korabecny J., Nepovimova E., Spilovska K., Andrs M., Babkova K., Musilek K., Soukup O., Kuca K.

Halogenated Pyrazine-based Chalcones as Potential Antimicrobial Agents
Kučerová-Chlupáčová M., Vyškovská-Tyllová V., Richterová-Finková L., Opletalová V.

11:45-12:00  Coffee break (room S2155)
 

The role of size of aza-crown recognition moiety in cation-sensing azaphthalocyanine fluorescence indicators
Lochman L., Svec J., Zimcik P., and Novakova V.

Synthesis of substituted heterocycles using tris(2-furyl)phosphine gold (I)
Mikušek J., Matouš P., Kolenič M., Janoušek M., Pour M.

Complete synthesis of ultra long human skin ceramides
Opálka L., Vávrová K.

Recent outcomes of novel modifications on the structure of salicylanilides Paraskevopoulos G., Monteiro S. E. A., Vinšová J.

  Lunch
14:00

Synthesis and biological evaluation of new prepared N-alkyl-3-(alkylamino)pyrazine-2-carboxamides and their precursors
Semelková L., Zitko J., Paterová P., Doležal M.

The structure-activity relationship study of 3,5-dinitrobenzylsulfanyl heteroaromates, new highly efficient antimycobacterial agents
Valášková L., Roh J., Karabanovich G., Němeček J., Stolaříková J., Vávrová K., Klimešová V., Hrabálek A.

Alkylamino derivatives of N-phenylpyrazine-2-carboxamide: Synthesis and antimycobacterial evaluation
Vaňásková B., Zitko J., Paterová P., Doležal M.

Coupling approach to pyrazine-2,3-dicarbonitriles with π-extended linkers between donor (N,N-dimethylamino) and acceptor moieties *
Cidlina A., Novakova V., Zimcik P.

15:05-15:15  Break
 

Evaluation of transdermal permeation enhancers based on terpenes *
Kopecna M., Machacek M., Roh J., Vavrova K.

The Effect of Stereochemistry at C-3 of Ceramides NS and NdS on the Permeability and Microstructure of Model Stratum Corneum Lipid Membranes *
Kovacik A., Pullmannova P., Zbytovska J., Palat K., Vavrova K.

1,2,5-Chalcogenadiazole-annulated tripyrazinoporphyrazines *
Svec J., Novakova V., Zimcik P., Stuzhin P.A.

Salicylanilide derivatives and their conjugation with peptide carriers *
Vosátka R., Krátký M., Vinšová J.

Tuesday 3. 2. 2015, Lecture Hall B 

 

Pharmacology and Toxicology Section

Chairman: Doc. PharmDr. Petr Nachtigal, Ph.D.; Doc. PharmDr. Přemysl Mladěnka, Ph.D.

9:05

CD44v6 receptor may interact with tumor associated cell surface proteins
Barta P., Sterberg J., Spiegelberg D., Nestor M., Trejtnar F.

Chrysin, balcalein and galangin are indirect activators of the human constitutive androstane receptor (CAR)
Carazo A., Smutny T., Hyrsová L., Berka K., Pavek P.

Radiolabeling of antibody IgG M75 for epitope of human carbonic anhydrase IX by 61Cu and 64Cu
Čepa A., Ráliš J., Pavelka A., Seifert D., Sieglová I., Král V., Polášek M., Paurová M., Lebeda O., Lázníček M.

9:50-10:15  Coffee break (room S2155)
 

Long term administration of tenofovir or emtricitabine to pregnant rats does not affect Abcb1a, Abcb1b, and Abcg2 expression in maternal and fetal cells
Cerveny L., Neumanova Z., Karbanova S., Havlova I., Staud F.

PD0332991 reverses ABC transporter-mediated multidrug resistance and synergizes with cancer chemotherapeutics in human transporter expressing MDCKII and in MCF-7 cell lines
Cihalova D., Ceckova M., Staud F.

Soluble endoglin effects on endothelial cells (HUVECs) - a pilot study
Fikrova P., Varejckova M., Jezkova K., Rathouska J., Dolezelova E.,  Nemeckova I., Nachtigal P.

In vitro effects of flavonoids on the arachidonic acid pathway of platelet activation
Filipský T., Karlíčková J., Říha M., Macáková K., Hrdina R., Mladěnka P.

11:20-11:40  Coffee break (room S2155)
 

Organic cation transporter 1 is down-regulated by pregnan X receptor in HepaRG cell line and primary human hepatocytes
Hyršová L., Gerbal-Chaloin S., Pavek P.

Characterization of endothelial function in aorta of transgenic mice overexpressing human soluble endoglin
Jezkova K., Rathouska J., Nemeckova I., Serwadczak A., Chlopicki S., Nachtigal P.

Il-1 receptor blocade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats
Kadova Z., Dolezelova E., Cermanova J., Staud F., Micuda S.

Interactions of steviol with selected efflux transporters and their impact on transport of trimethoprim
Mandíková J., Volková M., Navrátilová L., Pávek P., Trejtnar F.

Vasodilatory effects of quercetin and its metabolites on vascular smooth muscle in healthy and spontaneously hypertensive rats
Najmanová I., Vopršálová M., Mladěnka P.

Functional and molecular aspects of chronic sunitinib cardiotoxicity in rats.
Němečková I., Lenčová O., Jirkovský E., Adamcová M., Geršl V., Nachtigal P., Štěrba M.

  Lunch
14:00

Interactions of abacavir with placental nucleoside transporters
Neumanová Z., Červený L., Čečková M., Greenwood S.L., Štaud F.

The role of nucleoside transporters in a transfer of thymidine and abacavir across the human trophoblast microvillous membrane
Čečková M., Neumanová Z., Červený L., Glazier J., Štaud F.

Combination of high soluble endoglin levels and high fat diet affects aortic endothelium in mice
Rathouska J., Jezkova K., Nemeckova I., Serwadczak A., Bernabeu C., Lopez-Novoa J.M., Chlopicki S., Nachtigal P.

Role of endoplasmic reticulum stress in melanoma resistance to small – molecule inhibitors of MAPKs pathway 
Rozkydalová L., Vincent L.A., Cuq P., Mičuda S., Štaud F.

Emtricitabine is a substrate of MATE1, but does not interact with P-glycoprotein, BCRP, MRP2, OCT1 or OCT2 transporters
Reznicek J., Ceckova M., Neumanova Z., Cerveny L., Staud F.

15:15-15:25 Break
 

In vitro interactions of isoflavonoids with iron and copper
Říha M., Macáková K., Karlíčková J., Filipský T., Horňasová V., Hrdina R., Mladěnka P.

Novel class of activators of pharmacologically important nuclear receptors
Smutný T., Carazo A., Špulák M., Pour M., Pávek P.

Determination of ATV treatment effects on endoglin and eNOS expression in endothelial cells in vitro.
Varejckova M., Zemankova L., Fikrova P., Jezkova K., Rathouska J., Nemeckova I., Nachtigal P.

AChE modulators affect cholinergic receptors *
Sepsova V., Zdarova J.K., Soukup O.

Interaction of the intestinal transporter hOATP2B1 with selected natural compounds *
Navrátilová L., Mandíková J., Trejtnar F.

Tuesday 3. 2. 2015, Lecture Hall N  

 

Pharmaceutical Analysis Section

Chairman: Doc. RNDr. Dalibor Šatínský, Ph.D.; Doc. PharmDr. Petra Kovaříková, Ph.D.; Doc. PharmDr. Hana Sklenářová, Ph.D.

9:05

How diluents used in the sensing phase of an electrochemical genosensor affect to the genosensor performance
Aufartová J., Martín-Fernández B., Sánchez-Paniagua López M., Solich P., López-Ruiz B.

LC-MS/MS method for analysis of aroylhydrazone pro-chelator and its active form in plasma; Application to a pilot pharmacokinetic study
Bures J., Filipsky T., Premysl M., Klimes J., Kovarikova P.

UHPLC method development for determination of important antioxidants
Červinková B., Kujovská Krčmová L., Hutníková M., Solichová D., Solich P.

Development of UHPSFC-PDA method for determination of tocopherols and tocotrienols
Gottvald T., Pilařová V., Jakubec P., Benešová K., Běláková S., Nováková L., Solich P.

10:10-10:35  Coffee break (room S2155)
 

Development of UHPLC-MS/MS method for determination of vancomycin in surgical patients with important sequestration of liquids
Javorská L., Kujovská Krčmová L., Kučerová K., Solichová D., Kaška M., Solich P.

Monitoring of septic conditions by biological markers
Jenčo J., Kujovská Krčmová L., Netriová J., Solich P.

Methods for analysis of vitamin D in milk
Kasalová E., Aufartová J., Kujovská Krčmová L., Solichová D., Solich P.

Zirconia based sorbents for solid phase extraction of methotrexate from biological matrices
Klivický M., Kučera R., Klimeš J.

11:40-12:00  Coffee break (room S2155)
 

Pharmacokinetic study of the transport of a fluorescent marker through cell monolayer using SIA systém
Lopes E., Zelená L., Sklenářová H.; Segundo M., Pávek P.

A model of natural degradation of 17-α-ethinylestradiol in surface water and identification of degradation products by GC-MS
Nejedly T., Klimes J.

Solid-phase microextraction– isolation of thiosemicarbazone anti-cancer agents and evaluation of novel sorbents
Stariat J., Klivicky M., Kucera R., Pawliszyn J., Kovarikova P.

Synthesis of molecularly imprinted material for solid-phase extraction of β-N- methylamino-L-alanine from cyanobacterial extract
Svoboda P., Combes A., Petit J., Nováková L., Pichon V.

  Lunch
14:00

Theoretical and practical aspects of a Generalized Calibration Strategy implemented to flow techniques
Świt P., Chocholouš P., Wieczorek M., Kozak J., Solich P., Kościelniak P.

UHPLC-MS/MS Analysis of Thiosemicarbazone Iron Chelators – a Pharmacokinetic Study
Šesták V., Stariat J., Mičuda S., Chládek J., Štěrba M., Roh J., Bureš J., Richardson D.R., Kovaříková P.

Application of the sequential injection technique for automation of sample pretreatment in pharmaceutical analysis
Šrámková I., Horstkotte B., Sklenářová H., Šatínský D., Chocholouš P., Solich P.

Gradient chromatographic method for the determination of sotalol and sorbate in pediatric oral liquid preparations
Zahalka L., Zahalkova O., Matysova L., Klovrzova S., Sklubalova Z., Solich P.

Sample pretreatment in determination of efavirenz in OptiMEM® Reduced Serum Media using high-performance liquid chromatography with UV detection
Zelená L., Řezníček J., Čečková M., Sklenářová H.

Study of ochratoxin A and citrinin content in Czech lager beers by fast method using direct sample injection combined with fused core column on-line SPE-HPLC with fluorescence detection *
Lhotská I., Šatínský D., Havlíková L., Solich P.

Comparison of 3 multistatin MEPS-UHPLC-MS/MS methods for determination of 17 statins and related compounds in human serum *
Vlčková H., Svoboda P., Novák O., Nováková L., Solich P.

Wednesday 4. 2. 2015, Lecture Hall N

 

Section of Pharmacognosy and Toxicology of Natural Products

Chairman: Prof. RNDr. Lubomír Opletal, CSc.

8:30

Keynote lecture
Fumaria officinalis alkaloids and their biological activities related to Alzheimerʼs disease
Chlebek J., Novák Z., Opletal L., Hošťálková A., Ločárek M., Cahlíková L.

9:00

Phytochemical study of individual plant species of Bergenia genus
Hendrychová H., Tůmová L.

Alkaloids from Peumus boldus Mol. and Their Biological Activity
Hošťálková A., Kuneš J., Novák Z., Hrabinová M., Opletal L.

Identification of MRE in Promoter of Flavonol Synthase
Kubeš J., Stracke R., Tůmová L., Weisshaar B.

9:50-10:10  Coffee break (room S2155)
 

Rapid auxin metabolite profiling for high-throughput Arabidopsis screening
Pilařová V., Novák O., Pěnčík A., Casanova-Saez R., Ljung K., Nováková L., Solich P.

Alkaloids of some Narcissus Species and their Biological Activity
Šafratová M., Opletal L., Benešová N., Novák Z., Hrabinová M., Cahlíková L.

Isoquinoline alkaloids from Fumaria officinalis and their biological activities related to Alzheimer´s disease *
Hulcová D., Chlebek J., Novák Z., Opletal L., Kuneš J., Cahlíková L.

Alkaloids of Vinca minor L. and their effect on activity of selected enzymes as benefit to progress of Alzheimer's disease *
Ločárek M., Opletal L.

   
 

Pharmaceutical Technology Section

Chairman: doc. PharmDr. Zdeňka Šklubalová, Ph.D

13:00

Compressibility of pellets made from microcrystalline cellulose
Ondrejček P., Svačinová P., Stoniš J., Jirásková J., Rabišková M.

Organization of Ceramides with Long (C16) and Very Long (C24) Acyls in Model Stratum Corneum Membranes
Skolova B., Pullmannova P., Hudska K., Slepicka P., Vavrova K.

Development of Orodispersible Tablets I: Introduction Study
Stoniš J., Šklubalová Z., Ondrejček P., Svačinová P.

Influence of lubricants on viscoelastic properties of tablets
Svačinová P., Ondrejček P., Stoniš J., Jirásková J., Rabišková M.

Study of flow properties of sorbitol and its fractions *
Hurychová H., Šklubalová Z.

Wednesday 4. 2. 2015, Lecture Hall B

 

Pathobiochemistry and Xenobiochemistry Section

Chairman: Prof. RNDr. Lenka Skálová, Ph.D.; Doc. PharmDr. Iva Boušová, Ph.D.

8:30 Keynote lecture
Anthracycline-induced DNA damage: Methods of detection

Jirkovská A., Fikrová P., Šimůnek T.

´9:00

Purification of membrane-bound carbonyl-reducing enzymes using in-house developed affinity carrier
Andrýs R., Zemanová L., Lenčo J., Wsól V.

Potential protective effect of nitrites and 3-morpholinosydnonimine against anthracycline-induced cardiotoxicity in vitro 
Jansova H., Vostatkova L., Simunek T.

An insight into cell death process after photodynamic treatment of cancer cells with phthalocyanines and their aza-analogues
Macháček M., Brázdová P., Nováková V., Cidlina A., Rudolf E., Zimčík P., Šimůnek T.

Metabolic pathways of anthelmintic drug monepantel in sheep and its parasite (Haemonchus contortus)
Stuchlíková L., Jirásko R., Vokřál I., Valát M., Lamka J., Szotáková B., Holčapek M., Skálová L.

10:05-10:20   Coffee break (room S2155)
 

Iron metabolism of the tumour-initiating cells
Rychtarčíková Z., Lettlova S., Truksa J.

Neuroprotection by iron chelation in cellular model of Parkinson’s disease *
Hašková P., Jansová H., Šimůnek T.

Evaluation of potential reference genes for Real-Time PCR studies in Haemonchus contortus *
Lecová L., Růžičková M., Matoušková P., Skálová L.

The effect of catechins on selected biotransformation enzymes *
Lněničková K., Szotáková B.

Description and evaluation of DHRS8 biochemical properties *
Lundová T., Zemanová L., Štambergová H., Havránková J., Šafr M., Wsól V.

   
 

Section of Clinical and Social Pharmacy

Chairman: prof. RNDr. Jiří Vlček, CSc.; prof. PharmDr. Petr Pávek, Ph.D.

13:00

Delays in tuberculosis diagnosis and treatment in a high-burden country: risk factors in patients with drug-susceptible and multidrug-resistant tuberculosis
Belkina T., Khodjiev D., Tebbens J., Vlcek J.

Analysis of medication adherence and use of complementary and alternative medicines among chronically treated patients
Ladova K., Drapakova T., Matoulkova P., Kotlarova J., Pokladnikova J.

Adherence to calcium and vitamin D supplementation in postmenopausal women – baseline and follow-up
Touskova T., Vytrisalova M.

Jewish pharmacists in pharmacies in the interwar Czechoslovakia and their lives during World War II *
Arndt T.

Prevalence of drug-related problems among patients with chronic kidney disease *
Dvorackova E., Stara D., Vlcek J.


 

* Short lectures marked with red asterisk will be presented in Czech/Slovak language.

 

Postdoci II UK, reg. č. CZ.1.07/2.3.00/30.0061

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