Group of Experimental Pharmacokinetics

Charles University in Prague

Faculty of Pharmacy in Hradec Kralove, Czech Republic

Department of Pharmacology and Toxicology

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Head: Prof. PharmDr. Frantisek Staud, Ph.D.

Colleagues:
PharmDr. Martina Ceckova, Ph.D.
PharmDr. Lukas Cerveny, Ph.D.

Current PhD students:
Mgr. Daniela Cihalova
Mgr. Zuzana Neumanova
Mgr. Jakub Hofman
Mgr. Davoud Ahmadimoghaddam

Past PhD students:
PharmDr. Martina Ceckova, PhD
PharmDr. Antonin Libra, PhD
PharmDr. Lukas Cerveny, PhD
PharmDr. Zuzana Vackova, PhD
PharmDr. Leos Fuksa, PhD
PharmDr. Lenka Cygalova, PhD
PharmDr. Lucie Svecova, PhD
PharmDr. Eva Brcakova, PhD


From left to right: Leos, Zuzana, Lukas, Martina, Petr, Frantisek, Antonin
To see other, less formal photos of our group, click here.

Ongoing research projects:
Role of OCT3 and MATE1 transporters in the placenta
Highly active antiretroviral therapy (HAART) in pregnant women; effect of placental ABC/SLC transporters on mother-to-fetus transport of antiretroviral compounds
Inhibition of Breast Cancer Resistance Protein (BCRP/ABCG2) by Purine Cyclin-dependent Kinase Inhibitors In Vitro and In Situ
Detoxication role of the placenta - drug transport and metabolism.
Functional evaluation of ABC efflux transporters and cationic transporters in dually perfused rat placenta and HRP-1 placental cell line.
Functional expression of ABC transporters in the BeWo cell line.
Interactions of antiepileptics with ABC transporters.
siRNA for gene silencing of selected ABC transporters.
Corticosterone metabolism in the rat placenta.
Drug inductions of ABC transporters.

Professorship lecture on "Detoxication role of the placenta - importance of drug efflux transporters and biotransformation enzymes".
See powerpoint presentations of Drug transporters and their role in pharmacokinetics symposium (55. CESKO-SLOVENSKE FARMAKOLOGICKE DNY in Hradec Kralove, 31. 8. - 2. 9. 2005)

Professor PharmDr. Frantisek Staud, PhD

Head of the Department of Pharmacology and Toxicology
Pharmaceutical Faculty
Heyrovskeho 1203
500 03 Hradec Kralove
Czech Republic
Tel.: +420-495067407
email: frantisek.staud(at)faf.cuni.cz

Current and past research interests:

Detoxication role of the placenta - drug transport and metabolism in umbilically/dually perfused rat placenta and placenta-derived cell lines. Drug interactions with efflux transporters and biotransformation enzymes. RNA interference for functional genomics of drug efflux transporters. Overcoming biological barriers for cancer gene therapy; application of fluorescence microscopy for tracing plasmid DNA and its expression in tumor tissues in vivo; modification of gene expression by steroids in in vitro cell cultures; targeted delivery of macromolecules in the rat in vivo; effect of radioactive labeling on pharmacokinetic analysis of macromolecules; identification of factors controlling liver uptake and hepato-biliar transfer of macromolecules; gene-delivery using cationic liposomes and polypeptides.

Curriculum Vitae:

Grants:

  1. Interactions of Breast Cancer Resistance Protein (BCRP/ABCG2) and Purine Cyclin-dependent Kinase Inhibitors In Vitro and In Situ.
  2. Localization and function of Organic Cation Transporter 3 (OTC3) in the Rat Placenta
  3. In-vitro study of molecular-genetic cause of cell resistance against selected drugs.
  4. Investigation of drug efflux transporters using RNA interference and transfected cell lines
  5. Cytochrome P450 3A4 and multidrug resistance proteins MDR1 and MRP2 as main cause of drug interaction during elimination of drugs from organism.
  6. RNA interference in transepithelial transport studies
  7. Study of interactions of antiepileptic drugs with efflux transporters (BCRP, MRP2 and P-glycoprotein) in vitro.
  8. Visualization of placental membrane transporters using fluorescence microscopy.
  9. Building laboratories of molecular pharmacology.

Non-research activities: When not in the lab or writing up yet another grant application, I am busy to entertain my family.
Life is too short to live it only once; so I live it twice. Next to science, I love to travel the world as a photographer for magazines and agents, see www.photostaud.com and www.phototravels.net

List of publications:


Created by F. Staud, last updated 2012-10-04