2005 Folia Pharm. Univ. Carol. 33 Pag. 87—93




DSC Analysis of Paracetamol Suppositories

Marie Musilová, Jitka Gabrielová

Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic



Summary

On measurements by means of DSC, linear regression was demonstrated between the value of the melting point of paracetamol and its concentration in the suppository base. The found values were, nevertheless, lower than those that would correspond to the incorporated amount of paracetamol. The differences in the found and declared concentrations were in less concentrated samples about 2 %, in the samples of higher paracetamol concentrations about 0.5 %.