Synthesis and Biological Evaluation of Some Ring-substituted (E)-3-Aryl-1-pyrazin-2-ylprop-2-en-1-ones

Marta Chlupáčová¹ (Marta.Chlupacova@faf.cuni.cz), Veronika Opletalová¹, Jiří Kuneš¹, Luís Silva¹, Vladimír Buchta¹, Lenka Dušková¹, Katarína Kráľová²

¹ Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic
² Comenius University in Bratislava, Faculty of Natural Sciences, Slovak Republic

Summary

Alkylated derivatives of (E)-3-(3-hydroxyphenyl)-, (E)-3-(4-chlorophenyl)-, (E)-3-phenyl-, (E)-3-(2-hydroxy-5-nitrophenyl)- and (E)-3-furyl-1-pyrazin-2-ylprop-2-en-1-ones were prepared by Claisen-Schmidt condensation of corresponding alkylated acetylpyrazines and aldehydes. The products were evaluated on antimycobacterial, photosynthesis-inhibiting and antifungal activity.