Antimycobacterial Quaternary Ammonium Salts of Piperidinylethyl Esters of Alkoxysubstituted Phenylcarbamic Acids

Karel Waisser¹ (waisser@faf.cuni.cz), Jozef Čižmárik², Jarmila Kaustová³

¹ Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic
² Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic
³ Department of Diagnosis Mycobacteria, Institute of Hygiene, Regional Institute of Public Health, Ostrava, Czech Republic

Summary

This work is focused on the investigation of the antimycobacterial activity of quarternary ammonium salts of piperidinylethyl esters of alkoxysubstituted phenylcarbamic acids. The work is a part of the investigation of basic substituted alkyl esters of alkoxysubstituted phenylcarbamic acids. The advantage of compounds is a low toxicity. The antimycobacterial activity of compounds under study was very low (with exception of compound 1b). It seems that the antimycobacterial activity increases with the lipohility. The promising activity of compound 1b indicates that it is an attractive direction of research.