Quinlukast Azaanalogues Preparation

Josef Jampílek, Martin Doležal (dolezalm@faf.cuni.cz), Jiří Kuneš

Research Centre LN00B125, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic

Summary

The syntheses of 5-[2-(quinolin-2-ylmethoxy)benzoyl]pyrazine-2-carboxylic acid and 6-{[4-(quinolin-2-ylmethoxy)phenyl]amino}pyrazine-2-carboxylic acid as new potential antileukotrienic agents have been described. Both target compounds were prepared by means of multisteps synthetic pathways; the synthetic approach, analytical and spectroscopic data of all newly synthesized compounds have been presented. The target acids could not be tested for their anticipated biological activities due to their total insolubility in all solvents.