Protein and Blood Cell Binding of Quinlukast

Alice Lázníčková (laznicko@faf.cuni.cz), Jiří Hofmann, Matěj Syrovátko, Milan Lázníček

Research Centre LN00B125, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic

Summary

Plasma protein binding and distribution to blood cells of a new antiasthmatic drug quinlukast (compound VUFB 19363) was determined in man, bovine and rat. Binding to plasma proteins was higher than 99.5 % for all species under study. No significant interspecies differences in plasma protein binding were determined. The drug was accumulated also in the blood cells; its concentration in the cell compartment markedly exceeded that in water phase. In whole blood the drug was mostly in the form bound to proteins in plasma, the fraction distributed in blood cell compartment being substantially lower (lesser than 5 %).