Biological activity of N-substituted thiobenzamides and related compounds

Martin Šustr, Dáša Hrnčiarová, Marcela Látalová, Martin Pravda, Lenka Kubicová (kubicova@faf.cuni.cz)

Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic

Summary

The present review paper with 155 references links up with the previous communications reviewed biological activity of salicylanilides, thiosalicylanilides, thiobenzanilides, benzanilides, and other compounds based on the structure of carboxylic acids, and includes the research carried out in recent years. The paper surveys the research of biologically active compounds containing in the molecule the N-substituted (thio)amide group, bonded to aromatic or aliphatic structures or also to some heterocyclic systems. In the last period, a number of articles contributing to the knowledge about antimycobacterial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, photosynthesis-inhibiting, and antialgal activity of thiobenzanilides and related compounds (e.g. thiosalicylanilides, dihydroxy and trihydroxybenzamides) have been published.