3-Benzyl-2H-1,3-benzoxazine-2,4(3H)-diones, the new group of potential antituberculotics

Karel Waisser¹ (waisser@faf.cuni.cz), Milan Peřina¹, Jarmila Kaustová² (jarmila.kaustova@khsova.cz)

¹ Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic
² National Reference Laboratory for Mycobacterium kansasii, Institute of Hygiene, Ostrava, Czech Republic

Summary

3-benzyl-2H-1,3-benzoxazine-2,4(3H)-diones can be considered as new group of potential antituberculotics. The disadvantage of the compounds is small water-solubility. They belong to middle active potential antituberculotic and for increase the activity are expecting the QSAR studies, molecular modelling and other synthesis.