Antiproliferative and cytotoxic activities of derivatives of 3-aryl-2H-1,3-benzoxazine-2,4(3H)-dione

Hans-Martin Dahse¹ (hmdahse@pmail.hki-jena.de), Ute Möllmann¹, Karel Waisser² (waisser@faf.cuni.cz), Karel Palát Jr.², Otakar Bureš², Pavel Holý²

¹Hans Knöll Institute of Natural Products Research, Jena, Germany,
²Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic

Summary

Benzoxazine derivatives are known as potential antimycobacterial agents. The cytotoxicity and the proliferation activity of the selected group of compounds with extremely high antimycobacterial activity were studied. The synthesis of the compounds was not published, yet, because we would like to patent of this group. We have found on the basis of this study that the compounds under the study are cytotoxic and the development of new drugs is very problematic.