Molecular Aspect of the Development of Antimycobacterial Agents

Karel Waisser¹ (waisser@faf.cuni.cz), Karel Palát Jr.¹, Jiří Kuneš¹, Želmíra Odlerová²

¹Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
²Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic

Summary

This paper aims at determining whether the mechanism of action of several groups of new potential antituberculotics developed at the Faculty of Pharmacy, Charles University, Hradec Králové, is related to the processes in the cell wall of mycobacteria. A simple test for the estimation of the loss of bacterial acidoresistance has been employed in this study. It has been found that the acidoresistance of Mycobacterium tuberculosis is completely lost upon exposure to two new potential antituberculotics, 2-benzothiazolcarboxamide 6, and 3-(4-tolyl)-1,2-dihydroquinoxaline-2-thione 7. It is possible to conclude that the mechanism of their action consists in the intervention into the formation of the cell wall.