| 1999 | Folia Pharm. Univ. Carol. 24 | Pag. 33—39 |
Marie Musilová (musilova@faf.cuni.cz), Milan Řehula, Hubert Žáček, Alice Kaločová
Institut für Pharmazeutische Technologie, Karls-Universität Prag, Pharmazeutische Fakultät, Hradec Králové, Tschechische Republik
Eleven various mixtures of suppository bases Witepsol H 15 and Witepsol E 75 were prepared. These mixtures were characterized by the time of total deformation of the suppositories and by the content of the solid phase which corresponded to the temperature of carrying out the testing of deformation. It was found that the pharmacopoeial requirements are not satisfied in samples for which the content of the solid phase in the suppository base is greater than 26 %. The tolerable temperature zone of the testing of the time of total deformation, i. e. ± 0.5 °C, is too large at the temperature of the mean of the corresponding zone 37 °C.