Homolytic Acetylation of 2-Pyrazinecarbonitrile

Veronika Opletalová¹ (opletalo@faf.cuni.cz), Jiří Hartl¹, Camille Domonhedo¹, Asmita Patel²

¹Department of Pharmaceutical Chemistry and Drug Control, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic
²School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, United Kingdom

Summary

Homolytic acetylation of 2-pyrazinecarbonitrile using pyruvic acid as a source of acetyl radical was studied. 5-Acetyl-2-pyrazinecarbonitrile was obtained as the main product. The yield ranged from 5 to 30 % depending on reaction conditions.