Biological Effects of Substances Similar to Salicylanilides: Thiobenzanilides

Karel Waisser (waisser@faf.cuni.cz), Lenka Kubicová, Hynek Dostál

Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic

Summary

The previous parts of the present authors’ series of review papers presented a survey of studies connected with biological activity of salicylanilides, thiosalicylanilides, derivatives of 3-aryl-2H,4H-benz[e][1,3]oxazine-2,4-dione and benzanilides. To complete the overall survey, it was to publish similar information on thiobenzanilides, which was the aim of the present review paper. It follows from the analysis that thiobenzanilides have hitherto been studied in a much smaller extent than other compounds similar to salicylanilides and their research is far from complete. They have been reported to show general antibacterial activity, antimycobacterial activity, antifungal activity, insecticidal activity and herbicidal activity. Because of their biological effects, some thiobenzanilides have been patented. Their research, however, is far from being complete and it can be said that we can expect a constant flow of new papers about them in the near future.