Ein Beitrag zur Penetrometrischen Prüfung Salbenartiger Zubereitungen

Hubert Žáček, Marie Musilová (musilova@faf.cuni.cz),

Institut für Pharmazeutische Technologie der Pharmazeutischen Fakultät der Karls-Universität, Hradec Králové, Tschechische Republik

English Summary

A Contribution to Penetrometric Testing of Ointment Preparations

It is shown that strict differentiation must be made between rheometric measurements carried out on several samples of one and the same ointment preparation and analogous measurements performed repeatedly on a single sample of such preparation. In the latter instance, the phenomenon of „rheeologic memory“ is proved which can have several consequences in the preparation of ointments. It is also shown that the coefficient of determination (square of the correlation coefficient) is a very good measure of the efficiency of penetrometric data.