| 1998 | Folia Pharm. Univ. Carol. 21—22 | Pag. 15—20 |
Pavla Žáčková1, Jiří Vlček2 (vlcek@faf.cuni.cz), Zdeněk Zadák4, Hubert Žáček3
1Institut für Pharmakologie und Toxikologie,
2Institut für Soziale und Klinische Pharmazie
3Institut für Pharmazeutische Technologie, Pharmazeutische Fakultät der Karls-Universität, Hradec Králové
4Gerontologisch-metabolische Klinik im Fakultätskrankenhaus, Hradec Králové, Tschechische Republik
Acute Toxicity of Sodium Humate
The purpose of this work was to access the acute toxicity of sodium humate obtained from home materials within the scope of its preclinic testing.
The acute toxicity was determined on the basis of probit method on two animal species (mice, rats) of both sex. Besides the calculation of LD50, dissection was carried out on the selected dead animals, and histologic study was performed on lung, kidney, liver and spleen in the the surviving ones.
The LD50 (in mg.kg-1) was found to be 108 and 106 in mice and 62 and 73 in rats, males and females respectively. The course of intoxication was more rapid in mice than it was in rats. In the acute stage of intoxication, lung, liver and kidney were congested and the cause of death of the animals might be heart failure.
The acute toxicity of sodium humate of home origin is identical with that of foreign products and therefore is possible to take into consideration its therapeutic use in human and/or veterinary medicine.