| 1998 | Folia Pharm. Univ. Carol. 21—22 | Pag. 7—14 |
Milan Lázníček (laznicek@faf.cuni.cz), Olga Jindrová, Ivana Hamplová
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic
A comparison of lidocaine pharmacokinetics in mice, rats, guinea-pigs, rabbits, and man was made in this paper. Species differences exist in plasma protein binding; in animals 10 to 30 % of lidocaine is bound to plasma proteins whereas in man about 85 % of the drug is protein-bound. Also a certain degree of correlation was found between the free lidocaine fraction in plasma and both the distribution volume of the central compartment and the distribution volume at steady-state. As to elimination, a linear relationship in log-log scale was proposed between the value of lidocaine plasma clearance and body weight across all five mammalian species investigated. Considering the fact that lidocaine is highly extracted by the liver, only small interspecies differences in the ratios of lidocaine clearance-to-liver blood flow were found.