Relationships between the Chemical Structure of Substances
and their Antimycobacterial Activity to Atypical Strains.

VIII. 2-Alkylthio-4-Pyridinecarbonitriles

Věra Klimešová¹ (klimeso@faf.cuni.cz), Karel Waisser¹, Vladimír Buchta², Želmíra Odlerová³

¹Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic
²Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic
³Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic

Summary

2-Mercapto-4-pyridinecarbonitrile and a group of eleven 2-alkylthio-4-pyridinecarbonitriles were tested for their antimycobacterial activity against M. tuberculosis, M. kansasii, M. avium and M. fortuitum. The activity against M. fortuitum is very small. The activity of 2-mercapto-4-pyridinecarbonitrile and 2-hexylthio-4-pyridinecarbonitrile against atypical strains was higher than the activity of isoniazide and ethionamide.