Relationships between the Chemical Structure of Substances and their Antimycobacterial Activity to Atypical Strains.

VII. 2-Alkylthio-4-Pyridinecarbothioamides

Karel Waisser¹ (waisser@faf.cuni.cz), Věra Klimešová¹, Želmíra Odlerová²

¹Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic
²Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic

Summary

On the basis of the study of the relationships between the structure and antimycobacterial acitivity in the group of 2-alkylthio-4-pyridinecarbothioamides it has been demonstrated that the relationships between their structure and antimycobacterial activity against atypical strains (Mycobacterium kansasii, Mycobacterium avium, Mycobacterium fortuitum) are strongly dependent on the strain of the pertinent mycobacteria.