Relations Quantitatives Entre Structure Chimique et Hépatotoxicité des Dithiooxalamides

Karel Waisser¹ (waisser@faf.cuni.cz), Nestor Houngbedji¹, Jaroslav Dršata¹, Wilfried Thiel², Roland Mayer³

¹Faculté de Pharmacie, Université Charles, Hradec Králové, République Tchéque
²Arzneimittelwerk Dresden, Radebeul, Allemagne
³Université Technique Dresden, Allemagne

English Summary

Quantitative Chemical Structure—Hepatotoxicity Relationship of Dithiooxalamides

In a group of antituberculously effective derivatives of dithiooxalamide studied with a prospect of the develepment of novel antituberculous agents, hepatotoxity was found to correlate with the values of R_M from chromatography an thin layers of octadecylsilanized silica gel. Hepatotoxicity was evaluated by the activity of alaninamino transferase in blood serum.