Kidney Fragment Accumulation and Blood Cell Uptake of Some Organic Acids in Rats

Milan Lázníček (laznicek@faf.cuni.cz), Jiří Malina, Vít Svačina

Department of Pharmacology, Faculty of Pharmacy, Charles University, Hradec Králové

Summary

The effect of lipophilicity on the accumulation of a group of 10 iodine substituted weak organic acids (benzoic, phenylacetic and hippuric acid derivatives) in the renal tissue of rats was studied and compared with that of the blood cell uptake as the model of a different cell type. Whereas the degree of accumulation of the studied compounds into the renal tissue decreased with increasing lipophilicity, the dependence of blood cell uptake of these compounds on lipophilicity was of just opposite character. The rate of renal excretion of model drugs under study was proportional to the degree of their accumulation in the renal tissue.