N-Isonicotinoyl Dipeptide Derivatives

Jarmila Vinšová (vinsova@faf.cuni.cz)

Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, Hradec Králové 500 05, Czech Republic

Summary

The present study deals with the synthesis of optically active N-isonicotinoyl dipeptide derivatives as potential carriers of tuberculostatic active isoniazid. The appropriate N-isonicotinoyl dipeptide derivatives were prepared by the azide method from the corresponding dipeptide methyl esters and 4-pyridinecarboxylic acid azide. The pyridoyl hydrazides and acids were obtained by standard procedures.