Toxicology

Toxicology is an interdisciplinary scientific branch which studies toxicological aspects of pharmacology, pharmacognosy and drug development, botanical and chemical sciences, and ecology. The discipline is focused on toxicological aspects of all factors affecting the human organisms. Special attention is paid to toxic substances which are present in the air, water, food, plants, and environment, and as well as industrial toxins. Basic analytical methods for measuring concentrations of toxic substances in the air, water, food and in biological materials and the procedures in estimating drug toxicity are of primary importance and are taught in practical training settings which were created recently as an independent and obligatory subject followed by an examination.

Syllabus

Lectures

General toxicology

  • Mechanisms of toxic effect
  • Toxicokinetics (fate of toxicants in the body)
  • Chemical carcinogens and teratogens
  • Treatment of intoxication

Systemic toxicology

  • Responses of the respiratory system to toxic agents
  • Responses of the reproductive system to toxic agents
  • Responses of the liver to toxic agents
  • Responses of the kidney to toxic agents
  • Toxic agents
    Toxic effects of metals
    Toxic effects of solvents
    Toxic effects of environmental pollutants
  • Forensic toxicology

Phytotoxicology

  • Influence of natural (plant and fungal) toxins on human organism
  • Toxicologically significant plant and fungal constituents
  • Mycotoxins (micromycetes) and mushroom poisons (makromycetes)
  • The most important micromycetes and macromycetes with toxic properties
  • Imporant dangerous plants

There is no practical training with laboratory animals. Toxic effects are demonstrated via video.

 

Literature

© 2014 Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

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